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Lebedeva, Aleksandra
Publications (1 of 1) Show all publications
Tan, X., Lebedeva, A., Åkerstedt, T. & Wang, H.-X. (2023). Sleep Mediates the Association Between Stress at Work and Incident Dementia: Study From the Survey of Health, Ageing and Retirement in Europe. The journals of gerontology. Series A, Biological sciences and medical sciences, 78(3), 447-453
Open this publication in new window or tab >>Sleep Mediates the Association Between Stress at Work and Incident Dementia: Study From the Survey of Health, Ageing and Retirement in Europe
2023 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 78, no 3, p. 447-453Article in journal (Refereed) Published
Abstract [en]

Background: Both psychosocial stress at work and sleep disturbance may predispose impaired cognitive function and dementia in later life. However, whether sleep plays a mediating role for the link between stress at work and subsequent dementia has yet to be investigated.

Methods: Data from the Survey of Health, Ageing and Retirement in Europe were used for the study. A cohort of 7 799 dementia-free individuals (aged 71.1 ± 0.2 years) were followed up for a median of 4.1 years for incident dementia. Job demand and control were estimated using questions derived from the Karasek’s Job Content Questionnaire. Sleep disturbance was ascertained by a question in the EURO-Depression scale. Cox proportional hazard models adjusted for age, sex, education, cognitive test score, and other potential covariates were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia in relation to different job strain levels.

Results: An interaction between job demand and sleep disturbance regarding the risk of dementia was detected. Data suggested a protective role of high-level job demand for dementia in individuals with sleep disturbance (HR [95% CI]: 0.69 [0.47, 1.00]) compared with low job demand. A 4-category job strain model based on the combination of job demand and job control levels suggested that among individuals with sleep disturbance, passive job (low demand, low control) was associated with a higher risk of dementia (1.54 [1.01, 2.34]), compared to active job (high demand, high control).

Conclusion: The link between work-related stress and risk of dementia is limited to individuals suffering sleep disturbance.

Keywords
dementia, psychosocial stress, sleep
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-207225 (URN)10.1093/gerona/glac104 (DOI)000804829600001 ()35512268 (PubMedID)
Available from: 2022-07-11 Created: 2022-07-11 Last updated: 2024-01-30Bibliographically approved
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