Melanoma is the most common form of skin cancer, responsible for thousands of deaths annually. Novel therapies have been developed, but metastases are still a common problem, increasing the mortality rate and decreasing the quality of life of those who experience them. As traditional machine learning models for metastasis prediction have been limited to the use of a single modality, in this study we aim to explore and compare different unimodal and multimodal machine learning models to predict the onset of metastasis in melanoma patients to help clinicians focus their attention on patients at a higher risk of developing metastasis, increasing the likelihood of an earlier diagnosis.

We use a patient cohort derived from an Electronic Health Record, and we consider various modalities of data, including static, time series, and clinical text. We formulate the problem and propose a multimodal ML workflow for predicting the onset of metastasis in melanoma patients. We evaluate the performance of the workflow based on various classification metrics and statistical significance. The experimental findings suggest that multimodal models outperform the unimodal ones, demonstrating the potential of multimodal ML to predict the onset of metastasis.

Sepsis poses a significant threat to public health, causing millions of deaths annually. While treatable with timely intervention, accurately identifying at-risk patients remains challenging due to the condition’s complexity. Traditional scoring systems have been utilized, but their effectiveness has waned over time. Recognizing the need for comprehensive assessment, we introduce MASICU, a novel machine learning model architecture tailored for predicting ICU sepsis mortality. MASICU is a novel multimodal, attention-based classification model that integrates interpretability within an ICU setting. Our model incorporates multiple modalities and multimodal fusion strategies and prioritizes interpretability through different attention mechanisms. By leveraging both static and temporal features, MASICU offers a holistic view of the patient’s clinical status, enhancing predictive accuracy while providing clinically relevant insights.

Lung transplantation is a critical procedure performed in end-stage pulmonary patients. The number of lung transplantations performed in the USA in the last decade has been rising, but the survival rate is still lower than that of other solid organ transplantations. First, this study aims to employ machine learning models to predict patient survival after lung transplantation. Additionally, the aim is to generate counterfactual explanations based on these predictions to help clinicians and patients understand the changes needed to increase the probability of survival after the transplantation and better comply with normative requirements. We use data derived from the UNOS database, particularly the lung transplantations performed in the USA between 2019 and 2021. We formulate the problem and define two data representations, with the first being a representation that describes only the lung recipients and the second the recipients and donors. We propose an explainable ML workflow for predicting patient survival after lung transplantation. We evaluate the workflow based on various performance metrics, using five classification models and two counterfactual generation methods. Finally, we demonstrate the potential of explainable ML for resource allocation, predicting patient mortality, and generating explainable predictions for lung transplantation.