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Zuzek, R., Potter, M., Talley, N. J., Agreus, L., Andreasson, A., Veits, L., . . . Walker, M. M. (2024). Prevalence of Histological Gastritis in a Community Population and Association with Epigastric Pain. Digestive Diseases and Sciences, 69, 528-537
Open this publication in new window or tab >>Prevalence of Histological Gastritis in a Community Population and Association with Epigastric Pain
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2024 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 69, p. 528-537Article in journal (Refereed) Published
Abstract [en]

Background and Aims Gastritis is a common histological diagnosis, although the prevalence is decreasing in developed populations, alongside decreasing prevalence of H. pylori infection. We sought to determine the prevalence of the etiology of gastritis in a Swedish population sample and to analyze any associations with symptoms, an area of clinical uncertainty. Methods Longitudinal population-based study based in osthammar, Sweden. A randomly sampled adult population completed a validated gastrointestinal symptom questionnaire (Abdominal Symptom Questionnaire, ASQ) in 2011 (N = 1175). Participants < 80 years of age and who were eligible were invited to undergo esophagogastroduodenoscopy (EGD) (N = 947); 402 accepted and 368 underwent EGD with antral and body biopsies (average 54.1 years, range 20-79 years; 47.8% male) with H. pylori serology. Results Gastritis was found in 40.2% (148/368; 95% CI 35.2-45.2%). By rank, the most common histological subtype was reactive (68/148; 45.9%), then H. pylori (44/148; 29.7%), chronic non-H. pylori (29/148; 19.6%), and autoimmune (4/148; 2.7%). Gastritis was significantly associated with older age and H. pylori status (p < 0.01). Gastritis subjects were divided into three histological categories: chronic inactive inflammation, autoimmune gastritis, and active inflammation; there was no difference in the presence of upper gastrointestinal symptoms when categories were compared to cases with no pathological changes. Functional dyspepsia or gastroesophageal reflux were reported in 25.7% (38/148) of those with gastritis (any type or location) versus 34.1% (75/220) with no pathological changes (p = 0.32). Epigastric pain was more common in chronic H. pylori negative gastritis in the gastric body (OR = 3.22, 95% CI 1.08-9.62). Conclusion Gastritis is common in the population with a prevalence of 40% and is usually asymptomatic. Chronic body gastritis may be associated with epigastric pain, but independent validation is required to confirm these findings. Clinicians should not generally ascribe symptoms to histological gastritis.

Keywords
gastritis, H. pylori, endoscopy, epigastric pain, prevalence
National Category
Gastroenterology and Hepatology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-225806 (URN)10.1007/s10620-023-08170-2 (DOI)001125995700003 ()38091176 (PubMedID)2-s2.0-85179737644 (Scopus ID)
Note

The study was supported by Olympus (Box 1816, 171 23 Solna, Sweden), who supplied study equipment.

Available from: 2024-01-23 Created: 2024-01-23 Last updated: 2024-02-20Bibliographically approved
Andreasson, A., Tognetti, A., Jones, M., Lekander, M. & Lasselin, J. (2023). Assessing sickness behavior in the French: Validation of the French translation of the sickness questionnaire (SicknessQ) in a non-clinical French population. Brain, Behavior, & Immunity - Health, 34, Article ID 100708.
Open this publication in new window or tab >>Assessing sickness behavior in the French: Validation of the French translation of the sickness questionnaire (SicknessQ) in a non-clinical French population
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2023 (English)In: Brain, Behavior, & Immunity - Health, ISSN 2666-3546, Vol. 34, article id 100708Article in journal (Refereed) Published
Abstract [en]

The Sickness Questionnaire (SicknessQ) is a questionnaire developed to assess symptoms of sickness behavior, including somatic, behavioral, and affective dimensions. To promote cross-cultural assessments of sickness behavior, we aim to expand the use of this questionnaire to other populations and languages. The aim of the present study was to evaluate the French translation of SicknessQ in a French-speaking general population during the COVID-19 pandemic. One hundred and thirty-nine individuals completed the SicknessQ online, along with the construct criteria measures of self-rated health, state anxiety (STAI-S), and depressive symptoms (PHQ-9). The principal component analyses revealed two components: the first component included seven items concerning mood, motivation and experiences of fatigue and pain; the second component included three items concerning somatic sickness symptoms. Higher scores on the total scale and the two component subscales were associated with poorer self-rated health and higher STAI-S and PHQ-9 scores. Since the associations with construct criteria variables were relatively similar between the single- and the two-dimensional solutions, both the total scale and the subscales of the two components of the French SicknessQ can be used in future studies to measure sickness behavior in French-speaking populations.

Keywords
sickness behavior, questionnaire, French, fatigue, pain, mood
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-225013 (URN)10.1016/j.bbih.2023.100708 (DOI)001118055700001 ()2-s2.0-85177486252 (Scopus ID)
Funder
Swedish Research Council, 2020-01606Swedish Research Council, 2021–03184
Available from: 2024-01-04 Created: 2024-01-04 Last updated: 2024-01-16Bibliographically approved
Åslund, L., Andreasson, A., Lekander, M., Henje, E. & Dennhag, I. (2023). Disturbed sleep and patterns of psychiatric symptoms and function in a school-based sample of adolescents. Clinical Child Psychology and Psychiatry, 28(4), 1524-1535
Open this publication in new window or tab >>Disturbed sleep and patterns of psychiatric symptoms and function in a school-based sample of adolescents
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2023 (English)In: Clinical Child Psychology and Psychiatry, ISSN 1359-1045, E-ISSN 1461-7021, Vol. 28, no 4, p. 1524-1535Article in journal (Refereed) Published
Abstract [en]

Background Sleep problems are common in adolescence and often related to psychopathology and impaired functioning. However, most studies have used summative scores, and little is known about how adolescents with disrupted sleep perceive their specific symptoms and dysfunctions. This study explored differences in levels of psychiatric symptoms and functional ability between Swedish adolescents with and without self-reported disturbed sleep in a school-based sample.

Methods Swedish adolescents (n = 618, mean age 15.7+/-1.9yrs) answered the PROMIS pediatric measures for fatigue, anxiety, depression, pain interference, anger, physical activity and peer and family relationships. Logistic regression analyses were performed to assess differences between respondents with and without disturbed sleep.

Results Disturbed sleep was associated with higher levels of symptoms of fatigue, anxiety, depression, anger and pain interference, as well as lower functional abilities in terms of physical activity and peer- and family relationships. Adolescents reporting disturbed sleep generally displayed a pattern of impaired executive functioning, internal emotional distress and school- and sleep related worry and dysfunction, as compared to physical disability, aggressive behavior, stress and generalized worry.

Conclusions The present study adds to the understanding of how disturbed sleep and specific psychiatric symptoms and functional ability are interrelated, which may also have clinical implications.

Place, publisher, year, edition, pages
Sage Publications, 2023
Keywords
adolescent, sleep problems, psychiatric disorders, comorbidity, functional disability, PROMIS, physical activity, peer relationship, family relationship
National Category
Psychology Psychiatry
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-212689 (URN)10.1177/13591045221125479 (DOI)001075202700022 ()36167489 (PubMedID)2-s2.0-85139166298 (Scopus ID)
Note

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Svenska Sällskapet för Medicinsk Forskning (S253341) and Forskningsrådet om Hälsa, Arbetsliv och Välfärd (350-2012-303).

Available from: 2022-12-13 Created: 2022-12-13 Last updated: 2024-01-31Bibliographically approved
Alexandersson, B. T., Hugerth, L. W., Hedin, C., Forsberg, A., Talley, N. J., Agreus, L., . . . Schmidt, P. T. (2023). Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis: a population-based colonoscopy study. Scandinavian Journal of Gastroenterology, 58(10), 1131-1138
Open this publication in new window or tab >>Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis: a population-based colonoscopy study
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2023 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 58, no 10, p. 1131-1138Article in journal (Refereed) Published
Abstract [en]

Background: The etiopathogenesis of diverticular disease is unknown.

Objective: To compare the fecal and mucosa-associated microbiota between participants with and without diverticulosis and participants who later developed diverticulitis versus those that did not from a population-based study.

Methods: The PopCol study, conducted in Stockholm, Sweden, invited a random sample of 3556 adults to participate, of which 745 underwent colonoscopy. Overall, 130 participants (17.5%) had diverticulosis. 16S rRNA gene sequencing was conducted on available sigmoid biopsy samples from 529 and fecal samples from 251 individuals. We identified individuals who subsequently developed acute diverticulitis up to 13 years after sample collection. In a case-control design matching for gender, age (+/−5 years), smoking and antibiotic exposure, we compared taxonomic composition, richness and diversity of the microbiota between participants with or without diverticulosis, and between participants who later developed acute diverticulitis versus those who did not.

Results: No differences in microbiota richness or diversity were observed between participants with or without diverticulosis, nor for those who developed diverticulitis compared with those who did not. No bacterial taxa were significantly different between participants with diverticulosis compared with those without diverticulosis. Individuals who later developed acute diverticulitis (2.8%) had a higher abundance of genus Comamonas than those who did not (p = .027).

Conclusions: In a population-based cohort study the only significant difference was that those who later develop diverticulitis had more abundance of genus Comamonas. The significance of Comamonas is unclear, suggesting a limited role for the gut microbiota in the etiopathogenesis of diverticular disease.

Keywords
diverticulosis, diverticulitis, microbiota, population-based, colonoscopy, comamonas, mucosa-associated
National Category
Gastroenterology and Hepatology Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-216969 (URN)10.1080/00365521.2023.2194010 (DOI)000967810200001 ()36987880 (PubMedID)
Note

This work was Supported by grants provided by the Stockholm County Council (ALF project, grant number FoUI-953903), Signe och Olof Wallenius Stiftelse, Rut och Richard Julin’s Foundation (grant number 2020-00282), Stiftelsen Professor Nanna Svartz Foundation (grant number 2020-00358), and the Ragnar Söderbergs Stiftelse Foundation.

Available from: 2023-05-10 Created: 2023-05-10 Last updated: 2024-01-12Bibliographically approved
Hagström, H., Yan, J., Talbäck, M., Andreasson, A., Walldius, G., Bottai, M. & Hammar, N. (2023). Improved prediction of 10-year risk of severe liver disease in the general population using commonly available biomarkers. Alimentary Pharmacology and Therapeutics, 57(4), 418-425
Open this publication in new window or tab >>Improved prediction of 10-year risk of severe liver disease in the general population using commonly available biomarkers
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2023 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 57, no 4, p. 418-425Article in journal (Refereed) Published
Abstract [en]

Background: Estimating the risk for cirrhosis in the general population is complex. Existing prediction tools are in general unsatisfactory.

Aims: To explore if using commonly available biomarkers can improve the commonly used FIB-4 score in the identification of subgroups at risk of cirrhosis.

Methods: We used laboratory and clinical data on 126,925 individuals aged 35–79 years in Stockholm, Sweden, undergoing health examinations from 1985 to 1996. We used Swedish nationwide registries to ascertain 10-year cumulative incidence of severe liver disease, a composite of diagnoses corresponding to cirrhosis and its complications. We considered combinations of biomarkers associated with severe liver disease to identify subgroups with different risk profiles.

Results: During an average follow-up of 9.3 years, we ascertained 630 incident cases of severe liver disease (0.5%). Age, the FIB-4 score, diabetes or impaired glucose and gamma-glutamyl transferase (gGT) were the most relevant characteristics for classifying risk profiles. Using these factors, we identified 24 groups with a cumulative incidence of severe liver disease at 10 years ranging from 0.2% (age 35–65, low FIB-4, no diabetes or impaired glucose and normal gGT) to 32.1% (age 35–65, high FIB-4, diabetes or impaired glucose and high gGT).

Conclusions: Identification of subjects at increased risk of severe liver disease in the general population using the FIB-4 score can be substantially improved by adding age and specific biomarkers commonly available in the primary care setting. These parameters should be considered for inclusion in the development of future risk prediction models.

Place, publisher, year, edition, pages
John Wiley & Sons, 2023
Keywords
cirrhosis, biomarkers, FIB-4 score
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-214367 (URN)10.1111/apt.17374 (DOI)000901902700001 ()36566508 (PubMedID)2-s2.0-85145230132 (Scopus ID)
Note

HH was further supported by grants from the Swedish Research Council, the Swedish Cancer Society, Radiumhemmet Research Foundation and Region Stockholm. HH: institution has received research grants from Gilead, Intercept, EchoSens, MSD and Pfizer unrelated to the current study.

Available from: 2023-02-01 Created: 2023-02-01 Last updated: 2024-01-11Bibliographically approved
Alexandersson, B. T., Andreasson, A., Hedin, C., Broms, G., Schmidt, P. T. & Forsberg, A. (2023). Inflammatory Bowel Disease Is not Linked to a Higher Rate of Adverse Events in Colonoscopy: a Nationwide Population-based Study in Sweden. Journal of Crohn's & Colitis, 17(12), 1962-1967
Open this publication in new window or tab >>Inflammatory Bowel Disease Is not Linked to a Higher Rate of Adverse Events in Colonoscopy: a Nationwide Population-based Study in Sweden
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2023 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 17, no 12, p. 1962-1967Article in journal (Refereed) Published
Abstract [en]

Background and Aims: Inflammatory bowel disease may cause long-standing inflammation and fibrosis and may increase the risk of adverse events in colonoscopy. We evaluated whether inflammatory bowel disease and other potential risk factors are associated with bleeding or perforation in a nationwide, population-based, Swedish study.

Methods: Data from 969 532 colonoscopies, including 164 012 [17%] on inflammatory bowel disease patients, between 2003 and 2019, were retrieved from the National Patient Registers. ICD-10 codes for bleeding [T810] and perforation [T812] within 30 days of the colonoscopy were recorded. Multivariable logistic regression was used to test if inflammatory bowel disease status, inpatient setting, time period, general anaesthesia, age, sex, endoscopic procedures, and antithrombotic treatment were associated with higher odds for bleeding and perforation.

Results: Bleeding and perforation were reported in 0.19% and 0.11% of all colonoscopies, respectively. Bleeding [odds ratio 0.66, p <0.001] and perforation [odds ratio 0.79, p <0.033] were less likely in colonoscopies in individuals with inflammatory bowel disease status. Bleeding and perforation were more common in inpatient than in outpatient inflammatory bowel disease colonoscopies. The odds for bleeding but not perforation increased between 2003 to 2019. General anaesthesia was associated with double the odds for perforation.

Conclusions: Individuals with inflammatory bowel disease did not have more adverse events compared with individuals without inflammatory bowel disease status. However, the inpatient setting was associated with more adverse events, particularly in inflammatory bowel disease status. General anaesthesia was associated with a greater risk of perforation.

Keywords
gastrointestinal bleeding, perforation, inflammatory bowel disease
National Category
Gastroenterology and Hepatology Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-221271 (URN)10.1093/ecco-jcc/jjad114 (DOI)001030631500001 ()37402690 (PubMedID)2-s2.0-85182907131 (Scopus ID)
Note

This work was supported by the Regional Agreement on Medical Training and Clinical Research [ALF] between Stockholm County Council and Karolinska Institutet [FoUI-972885]; by the Swedish Society of Medicine, the Ihre Foundation [SLS-961196]; and by the Ruth and Richard Julin Foundation [Dnr 2021-00049].

Available from: 2023-09-25 Created: 2023-09-25 Last updated: 2024-02-01Bibliographically approved
Brew, B. K., Almqvist, C., Lundholm, C., Andreasson, A., Lehto, K., Talley, N. J. & Gong, T. (2022). Comorbidity of atopic diseases and gastro-oesophageal reflux evidence of a shared cause. Clinical and Experimental Allergy, 52(7), 868-877
Open this publication in new window or tab >>Comorbidity of atopic diseases and gastro-oesophageal reflux evidence of a shared cause
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2022 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 52, no 7, p. 868-877Article in journal (Refereed) Published
Abstract [en]

Introduction: Gastro-oesophageal reflux disease (GERD) is the most common non-allergic comorbidity in adults with asthma; however, comorbidity with other atopic diseases such as eczema and hay fever is unclear. The objective was to assess the comorbidity of GERD with asthma and atopic diseases and to investigate possible mechanisms, including genetic and/or affective factors.

Methods: A co-twin control study harnessing 46 583 adult twins. Questionnaires on health status were linked to national patient and prescribed drug register data. Analyses tested associations of comorbidity between multiple definitions of atopic diseases (self-report and register-based) with GERD. Comparisons were made between unpaired, monozygotic (MZ) and dizygotic (DZ) twins to assess genetic liability. Affective traits (depression, anxiety and neuroticism) were added to models as possible explanatory factors.

Results: The risk of GERD in those with asthma was OR (odds ratio) 1.52 (95% CI 1.38, 1.68), hay fever OR 1.22 (95%CI 1.12, 1.34) and eczema OR 1.23 (95%CI 1.10, 1.38). Adjusting for affective traits completely attenuated the comorbidity associations for hay fever and eczema with GERD, and partly for asthma with GERD. Co-twin control associations attenuated suggesting a shared cause for both GERD and atopic diseases. For example, all twins adjOR 1.32 (95%CI 1.00, 1.74), 0.97 (95% CI 0.76–1.23) and 1.11 (95%CI 0.85–1.45) for self-report asthma, hay fever and eczema with GERD respectively.

Conclusions: GERD is a common comorbidity in adults with asthma, hay fever and/or eczema. We found evidence for shared mechanisms suggesting common underlying causes that may involve affective traits requiring further investigation.

Keywords
asthma, comorbidity, eczema, gastro-oesophageal reflux, hay fever
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:su:diva-202625 (URN)10.1111/cea.14106 (DOI)000756047000001 ()35132702 (PubMedID)2-s2.0-85124628895 (Scopus ID)
Available from: 2022-03-09 Created: 2022-03-09 Last updated: 2022-08-19Bibliographically approved
Åström, J., Holmström, L., Karshikoff, B., Andreasson, A. & Kemani, M. K. (2022). Evaluating the construct validity and internal consistency of the Sickness Questionnaire in a Swedish sample of adults with longstanding pain. Scandinavian Journal of Pain, 22(1), 88-96
Open this publication in new window or tab >>Evaluating the construct validity and internal consistency of the Sickness Questionnaire in a Swedish sample of adults with longstanding pain
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2022 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 22, no 1, p. 88-96Article in journal (Refereed) Published
Abstract [en]

Objectives: Low-grade inflammation is a possible contributing factor in the development and persistence of chronic primary pain syndromes. Related to inflammatory activity is sickness behavior, a set of behavioral responses including increased pain sensitivity, fatigue, malaise, fever, loss of appetite, as well as depressive behavior and anhedonia. To capture these behavioral responses and their relation to longstanding pain, psychometrically sound self-report questionnaires are needed. The Sickness Questionnaire (SicknessQ) was developed to assess self-reported sickness behavior based on studies on acute immune activation while maintaining relevance for persistent conditions. The aim of the current study was to evaluate aspects of the validity and reliability of the SicknessQ in a Swedish sample of persons with longstanding pain.

Methods: Aspects of construct validity were evaluated by means of performing a confirmatory factor analysis (CFA) (testing structural validity) and by relevant hypothesis testing i.e., that ratings of sickness behavior in combination with other related factors (e.g., depression and anxiety) would be significantly related to ratings of avoidance. Reliability was evaluated by means of analyzing the internal consistency of items.

Results: Following the CFA, a non-significant Chi-Square test (chi(2) [32, N=190] = 42.95, p=0.094) indicated perfect model fit. Also, the relative fit indices supported adequate model fit (CFI = 0.978; TLI = 0.969; RMSEA = 0.0430). Sickness behavior (p<0.0001), depression (p<0.05) and pain duration (p<0.05) significantly contributed to the regression model, explaining 45% of the total variance in avoidance. Internal consistency was adequate, as indicated by a Cronbach's alpha value of 0.82 for the entire questionnaire.

Conclusions: Results indicate that the SicknessQ has adequate structural validity as well as adequate internal consistency, and is significantly associated with avoidance. The SicknessQ appears to have utility as a self-report questionnaire to assess symptoms of sickness behavior for adults with longstanding pain.

Keywords
avoidance, longstanding pain, reliability, sickness behavior, Sickness Questionnaire (SicknessQ), validity
National Category
Psychiatry Nursing
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-200435 (URN)10.1515/sjpain-2021-0070 (DOI)000731841600001 ()34931508 (PubMedID)
Available from: 2022-01-05 Created: 2022-01-05 Last updated: 2022-02-25Bibliographically approved
McNaughton, D. T., Andreasson, A., Ljótsson, B., Beath, A. P., Hush, J. M., Ljunggren, G., . . . Jones, M. P. (2022). Limited evidence of moderation of the association between gastrointestinal symptoms and prospective healthcare utilisation by quality of life. Alimentary Pharmacology and Therapeutics, 55(3), 311-317
Open this publication in new window or tab >>Limited evidence of moderation of the association between gastrointestinal symptoms and prospective healthcare utilisation by quality of life
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2022 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 55, no 3, p. 311-317Article in journal (Refereed) Published
Abstract [en]

Background: An individual’s drive to seek medical help remains a complex behavioural process, incorporating psychological, social and symptom-specific factors. Within irritable bowel syndrome (IBS), gastrointestinal symptoms only predict a small portion of the high healthcare-seeking experienced.

Aim: To examine the moderating role of quality of life (QoL) domains on this relationship to help explain the variance observed.

Methods: This is an analysis of a Swedish population-based prospective study of healthcare use over a 12-year period. At baseline, gastrointestinal symptoms were measured with the valid Gastrointestinal Symptom Rating Scale, and QoL via the SF-36. 1159 subjects (57% female; mean age 48.6 years) had their health records matched with the initial survey. 164 were classified as IBS by Rome II criteria. Negative binomial or logistic models were fit to evaluate the moderating effect of particular QoL domains on the relationship between gastrointestinal symptoms and prospective healthcare utilisation.

Results: Gastrointestinal symptoms were associated with prospective healthcare use, but moderation in this relationship by particular QoL domains was not supported; most models did not reach statistical significance. Furthermore, the impact of IBS status did not alter the moderation hypotheses.

Conclusions: Particular QoL domains did not impact the relationship between gastrointestinal symptoms on prospective healthcare seeking. Future research should continue to examine other psychological, social and symptom variables to identify predictors of high healthcare consumers in IBS.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:su:diva-204937 (URN)10.1111/apt.16651 (DOI)000708383100001 ()34664298 (PubMedID)2-s2.0-85117227629 (Scopus ID)
Available from: 2022-05-24 Created: 2022-05-24 Last updated: 2022-05-24Bibliographically approved
Andreasson, A., Talley, N. J., Walker, M. M., Jones, M. P., Platts, L. G., Wallner, B., . . . Agréus, L. (2021). An Increasing Incidence of Upper Gastrointestinal Disorders Over 23 Years: A Prospective Population-Based Study in Sweden. American Journal of Gastroenterology, 116(1), 210-213
Open this publication in new window or tab >>An Increasing Incidence of Upper Gastrointestinal Disorders Over 23 Years: A Prospective Population-Based Study in Sweden
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2021 (English)In: American Journal of Gastroenterology, ISSN 0002-9270, E-ISSN 1572-0241, Vol. 116, no 1, p. 210-213Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: We hypothesized that the prevalence of functional dyspepsia and gastroesophageal reflux disease in the community may be increasing.

METHODS: Randomly selected adults were surveyed on 4 occasions: 1988 (n = 1,151, 21–79 years, response rate [rr] = 90%), 1989 (n = 1,097, 22–80 years, rr = 87%), 1995 (n = 1,139, 20–85 years, rr = 76%), and 2011 (n = 1,175, 20–93 years, rr = 63%).

RESULTS: In functional dyspepsia, the odds of postprandial distress syndrome tripled over 23 years' follow-up (odds ratio [OR]: 3.55; 95% confidence interval [CI]: 2.60–4.84, mixed-effect regression analysis), whereas a small decrease in epigastric pain syndrome was observed (OR: 0.65, 95% CI: 0.42–1.00). The odds of reporting gastroesophageal reflux disease doubled (OR: 2.02; 95% CI: 1.50–2.73).

DISCUSSION: The underlying mechanisms behind the increase in postprandial distress syndrome and gastroesophageal reflux disease remain to be determined.

Keywords
functional dyspepsia, gastroesophageal reflux
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:su:diva-188404 (URN)10.14309/ajg.0000000000000972 (DOI)000607726100032 ()
Available from: 2021-01-07 Created: 2021-01-07 Last updated: 2022-02-25Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-0203-7977

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