Divisive structures: Two billions years of biofilament evolution
2020 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]
Our understanding of the functional and regulatory complexity that existed in the eukaryotic progenitor is poor, and investigations have been hindered by our nebulous understanding of where eukaryotes stem from. Recently discovered archaeal lineages with hitherto unseen homology to eukaryotic systems suggest archaea can further our understanding of the eukaryotic cell’s ancestry. However, much of archaeal biology remains largely unexplored. Two eukaryotic systems with archaeal homologues, namely the actin and ESCRT-III protein filament systems, are essential for diverse processes in eukaryotic biology. In this thesis, we show that an archaeal homologue of ESCRT-III divides the cell under proteasomal regulation, a regulatory mechanism central to eukaryotic cell cycle regulation. Additionally, we show how predicted putative profilin and gelsolin homologues regulate the postulated proto-cytoskeleton of Asgard archaea. In investigating the function and regulation of these archaeal systems we demonstrate compelling parallels between archaeal and eukaryotic regulatory strategies which stresses the close evolutionary relationship that exists between these two domains.
Place, publisher, year, edition, pages
Stockholm: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University , 2020. , p. 43
Keywords [en]
Evolution, Archaea, Eukaryogenesis, ESCRT-III, Actin, Profilin, Gelsolin, Asgard, TACK, Sulfolobus, Cell division, Cytokinesis, Cytoskeleton, Heimdallarchaeota, Actin-binding protein
National Category
Biochemistry and Molecular Biology
Research subject
Molecular Bioscience
Identifiers
URN: urn:nbn:se:su:diva-180989ISBN: 978-91-7911-058-1 (print)ISBN: 978-91-7911-059-8 (electronic)OAI: oai:DiVA.org:su-180989DiVA, id: diva2:1426171
Public defence
2020-06-12, Sal P216, NPQ-huset, Svante Arrhenius väg 20 A, digitally via Zoom: Zoom Meeting ID: 638-3943-9290, https://stockholmuniversity.zoom.us/j/63839439290, Stockholm, 10:00 (English)
Opponent
Supervisors
Funder
Swedish Research Council, 621 2013 4685Wellcome trust, 203276/F/16/Z
Note
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 1: Manuscript. Paper 2: Manuscript. Paper 3: Manuscript.
2020-05-182020-04-232022-02-26Bibliographically approved
List of papers