Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effect of Local Anesthetic Lidocaine on Electrostatic Properties of a Lipid Bilayer
Stockholm University, Faculty of Science, Department of Physical, Inorganic and Structural Chemistry. Stockholm University, Faculty of Science, Department of Physical, Inorganic and Structural Chemistry, Physical Chemistry.
Stockholm University, Faculty of Science, Department of Physical, Inorganic and Structural Chemistry, Physical Chemistry. (computational chemistry)ORCID iD: 0000-0002-9390-5719
2008 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 94, p. 525-531Article in journal (Refereed) Published
Abstract [en]

The influence of local anesthetic lidocaine on electrostatic properties of a lipid membrane bilayer was studied by molecular dynamics simulations. The electrostatic dipole potential, charge densities, and orientations of the headgroup angle have been examined in presence of different amounts of charged or uncharged forms of lidocaine. Important differences of the membrane properties caused by the presence of the both forms of lidocaine are presented and discussed. Our simulations have shown that both charged and uncharged lidocaine cause almost the same increase of the dipole electrostatic potential in the middle of membrane though for different reasons. The increase, being about 90 mV for 9 mol % of lidocaine and 220 mV for 28 mol% of lidocaine, is of the size which may affect the functioning of voltage-gated ion channels.

Place, publisher, year, edition, pages
2008. Vol. 94, p. 525-531
Keywords [en]
membranes; DMPC; lidocaine; molecular dynamics; electrostatics
National Category
Physical Chemistry
Research subject
Physical Chemistry
Identifiers
URN: urn:nbn:se:su:diva-28982DOI: doi:10.1529/biophysj.107.104208ISI: 000251924200022OAI: oai:DiVA.org:su-28982DiVA, id: diva2:228402
Projects
Advanced computer simulation methods for theoretical description of molecular systemsAvailable from: 2010-11-26 Created: 2009-07-30 Last updated: 2022-02-25Bibliographically approved

Open Access in DiVA

fulltext(439 kB)382 downloads
File information
File name FULLTEXT01.pdfFile size 439 kBChecksum SHA-512
e525b76c4c0fc4ef6828285930050ae21632463431256c8f9af0a0fa373dfa709f53ced1ada59dfbcc933539d7d2e1552ea9e5aa674ecd63de3e1e7b8ded5370
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records

Högberg, Carl-JohanLyubartsev, Alexander

Search in DiVA

By author/editor
Högberg, Carl-JohanLyubartsev, Alexander
By organisation
Department of Physical, Inorganic and Structural ChemistryPhysical Chemistry
In the same journal
Biophysical Journal
Physical Chemistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 382 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 405 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf