This study set out to investigate how biological dysregulation, in terms of allostatic load (AL), relates to selfrated health (SRH) in women. Data on SRH and 12 biomarkers used to assess AL were available for 241 employees from the health care sector and 98 employees from the IT/media sector. In line with the hypothesis, results showed that a poor SRH, along with occupational sector, age and education, were significantly associated with a high AL, particularly for those working withinthe health care sector. This association between a poor SRH and AL, suggests a link between SRH and biological dysregulation.