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Surface proteomics on nanoparticles: a step to simplify the rapid prototyping of nanoparticles
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Rekke forfattare: 42017 (engelsk)Inngår i: Nanoscale Horizons, ISSN 2055-6756, Vol. 2, nr 1, s. 55-64Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Engineered nanoparticles for biomedical applications require increasing effectiveness in targeting specific cells while preserving non-target cells' safety. We developed a surface proteomics method for a rapid and systematic analysis of the interphase between the nanoparticle protein corona and the targeted cells that could implement the rapid prototyping of nanomedicines. Native nanoparticles entering in a protein-rich liquid medium quickly form a macromolecular structure called protein corona. This protein structure defines the physical interaction between nanoparticles and target cells. The surface proteins compose the first line of interaction between this macromolecular structure and the cell surface of a target cell. We demonstrated that SUSTU (SUrface proteomics, Safety, Targeting, Uptake) provides a qualitative and quantitative analysis from the protein corona surface. With SUSTU, the spatial dynamics of the protein corona surface can be studied. Data from SUSTU would ascertain the nanoparticle functionalized groups exposed at a destiny that could circumvent preliminary in vitro experiments. Therefore, this methodcould implement in the analysis of nanoparticle targeting and uptakecapability andcouldbe integrated intoa rapidprototyping strategy which is a major challenge in nanomaterials science. Data are available via ProteomeXchange with the identifier PXD004636.

sted, utgiver, år, opplag, sider
2017. Vol. 2, nr 1, s. 55-64
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-140411DOI: 10.1039/c6nh00162aISI: 000391450000006OAI: oai:DiVA.org:su-140411DiVA, id: diva2:1080608
Tilgjengelig fra: 2017-03-10 Laget: 2017-03-10 Sist oppdatert: 2017-03-10bibliografisk kontrollert

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