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Computational models and tools
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.ORCID-id: 0000-0002-4160-1078
2018 (engelsk)Inngår i: Medical physics, ISSN 0094-2405, Vol. 45, nr 11, s. e1073-e1085Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In this chapter, we describe two different methods, analytical (pencil beam) algorithms and Monte Carlo simulations, used to obtain the intended dose distributions in patients and evaluate their strengths and shortcomings. We discuss the difference between the prescribed physical dose and the biologically effective dose, the relative biological effectiveness (RBE) between ions and photons and the dependence of RBE on the linear energy transfer (LET). Lastly, we show how LET- or RBE-based optimization can be used to improve treatment plans and explore how the availability of multimodality ion beam facilities can be used to design a tumor-specific optimal treatment.

sted, utgiver, år, opplag, sider
2018. Vol. 45, nr 11, s. e1073-e1085
Emneord [en]
dose calculation, LET, monte carlo, particle therapy, RBE
HSV kategori
Forskningsprogram
medicinsk strålningsfysik
Identifikatorer
URN: urn:nbn:se:su:diva-162541DOI: 10.1002/mp.12521ISI: 000449995900010PubMedID: 30421814OAI: oai:DiVA.org:su-162541DiVA, id: diva2:1267154
Tilgjengelig fra: 2018-11-30 Laget: 2018-11-30 Sist oppdatert: 2018-12-10bibliografisk kontrollert

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