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Adrenoceptors in white, brown, and brite adipocytes
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
Rekke forfattare: 42019 (engelsk)Inngår i: British Journal of Pharmacology, ISSN 0007-1188, E-ISSN 1476-5381, Vol. 176, nr 14, s. 2416-2432Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides (lipogenesis), the breakdown of stored triglycerides (lipolysis), thermogenesis (heat production), glucose metabolism, and the secretion of adipocyte-derived hormones that can control whole-body energy homeostasis. These processes are regulated by the sympathetic nervous system through actions at different adrenoceptor subtypes expressed in adipose tissue depots. In this review, we have highlighted the role of adrenoceptor subtypes in white, brown, and brite adipocytes in both rodents and humans and have included detailed analysis of adrenoceptor expression in human adipose tissue and clonally derived adipocytes. We discuss important considerations when investigating adrenoceptor function in adipose tissue or adipocytes.

sted, utgiver, år, opplag, sider
2019. Vol. 176, nr 14, s. 2416-2432
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-170820DOI: 10.1111/bph.14631ISI: 000472784200007PubMedID: 30801689OAI: oai:DiVA.org:su-170820DiVA, id: diva2:1339522
Tilgjengelig fra: 2019-07-30 Laget: 2019-07-30 Sist oppdatert: 2019-07-30bibliografisk kontrollert

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Bengtsson, ToreHutchinson, Dana S.
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