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Mitochondria orchestrate proteostatic and metabolic stress responses
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.ORCID-id: 0000-0001-8948-0685
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut. University of Graz, Austria.
Rekke forfattare: 32019 (engelsk)Inngår i: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 20, nr 10, artikkel-id e47865Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The eukaryotic cell is morphologically and functionally organized as an interconnected network of organelles that responds to stress and aging. Organelles communicate via dedicated signal transduction pathways and the transfer of information in form of metabolites and energy levels. Recent data suggest that the communication between organellar proteostasis systems is a cornerstone of cellular stress responses in eukaryotic cells. Here, we discuss the integration of proteostasis and energy fluxes in the regulation of cellular stress and aging. We emphasize the molecular architecture of the regulatory transcriptional pathways that both sense and control metabolism and proteostasis. A special focus is placed on mechanistic insights gained from the model organism budding yeast in signaling from mitochondria to the nucleus and how this shapes cellular fitness.

sted, utgiver, år, opplag, sider
2019. Vol. 20, nr 10, artikkel-id e47865
Emneord [en]
mitochondria-to-nucleus signaling, organellar connectivity, protein folding, proteostasis, stress response
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-175710DOI: 10.15252/embr.201947865ISI: 000486833800001PubMedID: 31531937OAI: oai:DiVA.org:su-175710DiVA, id: diva2:1369921
Tilgjengelig fra: 2019-11-13 Laget: 2019-11-13 Sist oppdatert: 2019-12-08bibliografisk kontrollert

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