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Cognitive and physical markers of prodromal dementia: A 12-year-long population study
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Stockholm Gerontology Research Centre, Sweden.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Catholic University, Italy; Fondazione Policlinico “A. Gemelli” IRCCS, Italy.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
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Rekke forfattare: 82020 (engelsk)Inngår i: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 16, nr 1, s. 153-161Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: The aim is to test whether adding a simple physical test such as walking speed (WS) to the neuropsychological assessment increases the predictive ability to detect dementia.

Methods: The 2546 dementia-free people from the SNAC-K study were grouped into four profiles: (1) healthy profile; (2) isolated cognitive impairment, no dementia (CIND, scoring 1.5 standard deviation below age-specific means on >= 1 cognitive domains); (3) isolated slow WS (<0.8 m/s); (4) CIND+ slow WS. The hazard of dementia (Cox regression), the positive and negative predictive values (PPV, NPV), and the area under the curve (AUC) were estimated.

Results: Participants with CIND +slow WS demonstrated the highest hazard of dementia (3.4; 95% confidence interval [CI]: 2.5-4.8). The AUC increased from 0.69 for isolated CIND to 0.83 for CIND+ slow WS. Such an increase was due to the improvement of the PPV, the NPV remaining optimal.

Discussion: Adding WS to the cognitive assessment dramatically increases the diagnostic accuracy of prodromal dementia.

sted, utgiver, år, opplag, sider
2020. Vol. 16, nr 1, s. 153-161
Emneord [en]
clinical markers, cognitive impairment, dementia, population-based study, walking speed
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-178643DOI: 10.1002/alz.12002ISI: 000506234500013PubMedID: 31914224OAI: oai:DiVA.org:su-178643DiVA, id: diva2:1399541
Tilgjengelig fra: 2020-02-28 Laget: 2020-02-28 Sist oppdatert: 2020-02-28bibliografisk kontrollert

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