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Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue's Competence for Cold-Induced Thermogenic Recruitment
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut. University Medical Center Hamburg-Eppendorf, Germany.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.ORCID-id: 0000-0001-8044-5410
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Rekke forfattare: 62020 (engelsk)Inngår i: Frontiers in Endocrinology, E-ISSN 1664-2392, Vol. 11, artikkel-id 568682Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Brown adipose tissue from mice living under conditions approaching human thermal and nutritional conditions (prolonged exposure to thermoneutral temperature and to an energy-rich (high-fat, high-sugar) diet) - referred to as physiologically humanized mice, displays morphological and molecular characteristics significantly different from those observed in young, chow-fed mice maintained at room temperature - referred to as standard mice. Here, we further examined brown fat from physiologically humanized and standard mice, as well as from mice exposed to thermoneutrality for a long time but not to an energy-rich diet - referred to here as long-term thermoneutral mice. Global transcriptome analysis of brown fat revealed that genes that were the most upregulated in brown fat of thermoneutral mice (both physiologically humanized and long-term thermoneutral) were those related to inflammatory processes, including genes expressed selectively in macrophages. Cellular and molecular analyses confirmed that brown fat from thermoneutral mice was heavily infiltrated by macrophages, predominantly organized into crown-like structures. However, despite this, the brown fat of thermoneutral mice retained full competence to attain the greatest possible recruitment state and became macrophage-depleted during the process of cold acclimation. Thus, profound macrophage accumulation does not influence the thermogenic recruitment competence of brown fat.

sted, utgiver, år, opplag, sider
2020. Vol. 11, artikkel-id 568682
Emneord [en]
brown fat, thermogenic capacity, UCP1, macrophages, thermoneutrality
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-188202DOI: 10.3389/fendo.2020.568682ISI: 000588782900001PubMedID: 33193086OAI: oai:DiVA.org:su-188202DiVA, id: diva2:1513176
Tilgjengelig fra: 2020-12-29 Laget: 2020-12-29 Sist oppdatert: 2024-01-17bibliografisk kontrollert

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Fischer, Alexander W.de Jong, Jasper M. A.Petrovic, Natasa

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