In a recent article, Wu et al.1 presented an electroencephalogram (EEG)-based prediction model for antidepressant treatment response1. Here, we point to limitations in the methods used to define response and to validate the prediction model—specifically, that change from baseline Hamilton depression rating scale (HAMD) scores needs to take into account the nonlinearity of response, and that the validation analysis transposed the predictor and the outcome.

1. ARISING FROM W. Wu et al. Nature Biotechnology. https://doi.org/10.1038/s41587-019-0397-3 (2020)