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Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder
Karolinska Institutet.
Karolinska Institutet.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen. Karolinska Institutet, Stockholm, Sweden.ORCID-id: 0000-0003-4531-4313
Karolinska Institutet.
Vise andre og tillknytning
2009 (engelsk)Inngår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 50, nr 1, s. 5-10Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Forty-two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH-1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision-making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior.

sted, utgiver, år, opplag, sider
Wiley , 2009. Vol. 50, nr 1, s. 5-10
Emneord [en]
borderline personality disorder, tryptophan hydroxylase-1 gene, serotonin, decision-making, Iowa Gambling Task
HSV kategori
Forskningsprogram
psykologi
Identifikatorer
URN: urn:nbn:se:su:diva-27716DOI: 10.1111/j.1467-9450.2008.00689.xISI: 000262487700003OAI: oai:DiVA.org:su-27716DiVA, id: diva2:217259
Merknad

This study was financially supported by grants from the Stockholm County Council, the Swedish Science Council, the AFA Insurance Company and by funds from the Karolinska Institute.

Tilgjengelig fra: 2009-05-13 Laget: 2009-05-13 Sist oppdatert: 2022-02-25bibliografisk kontrollert

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