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Mesostructured silica based delivery system for a drug with a peptide as a cell-penetrating vector
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi, Avdelningen för strukturkemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi, Avdelningen för strukturkemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi.ORCID-id: 0000-0001-5803-0817
2009 (engelsk)Inngår i: Microporous and Mesoporous Materials, ISSN 1387-1811, E-ISSN 1873-3093, Vol. 122, nr 1-3, s. 201-207Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A drug delivery system using mesostructured silica as a reservoir has been developed for the storage and controlled release of a drug with a cell-penetrating peptide (CPP) as a vector. We use fluorescein isothiocyanate (FITC) as the drug model and octaarginine (R8) as a vector to endow the drug with cell-penetrating property. The mesostructured silica reservoir system was prepared by using a one-pot liquid?crystal templating method, which is suitable for the encapsulation of intact FITC-R8 conjugates and sustained release of drugs without hampering their properties. The hydrophobic poly(propyl oxide) (PPO) shell of the pore-filling Pluronic F127 and the electrostatic interaction between R8 and siloxide ions on the pore walls act as the diffusion-limiting factors of the FITC-R8 conjugate. A sigmoidal in vitro release of FITC-R8 from mesostructured silica into phosphate buffered saline (PBS, pH 7.4) was observed and the typical release duration was 5 days at 37 ‹C. Release from the reservoir yielded significant elongation in duration of the FITC signals in DU145 cells by confocal microscopic analysis, compared with a single administration of FITC-R8.

 

sted, utgiver, år, opplag, sider
2009. Vol. 122, nr 1-3, s. 201-207
Emneord [en]
Mesostructured silica, Drug delivery, Cell-penetrating peptide, Sigmoidal release, Sustained cellular uptake
HSV kategori
Forskningsprogram
strukturkemi
Identifikatorer
URN: urn:nbn:se:su:diva-36704DOI: 10.1016/j.micromeso.2009.03.002ISI: 000266061500029OAI: oai:DiVA.org:su-36704DiVA, id: diva2:289969
Merknad
övrigt antal författare 7st.Tilgjengelig fra: 2010-01-25 Laget: 2010-01-25 Sist oppdatert: 2020-03-05bibliografisk kontrollert

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