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Age-Related Olfactory Decline is Associated with the BDNF Val66met Polymorphism: Evidence from a Population-Based Study
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Kognitiv psykologi.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.ORCID-id: 0000-0002-0856-0569
Department of Pharmacology, Göteborg University, Göteborg, Sweden.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Frontiers in Aging Neuroscience, ISSN 1663-4365, Vol. 2, nr 7, s. 24-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The present study investigates the effect of the brain-derived neurotrophic factor (BDNF) val66met polymorphism on change in olfactory function in a large scale, longitudinal population-based sample (n = 836). The subjects were tested on a 13 item force-choice odor identification test on two test occasions over a 5-year-interval. Sex, education, health-related factors, and semantic ability were controlled for in the statistical analyses. Results showed an interaction effect of age and BDNF val66met on olfactory change, such that the magnitude of olfactory decline in the older age cohort (70–90years old at baseline) was larger for the val homozygote carriers than for the met carriers. The older met carriers did not display larger age-related decline in olfactory function compared to the younger group. The BDNF val66met polymorphism did not affect the rate of decline in the younger age cohort (45–65years). The findings are discussed in the light of the proposed roles of BDNF in neural development and maintenance.

sted, utgiver, år, opplag, sider
2010. Vol. 2, nr 7, s. 24-
Emneord [en]
brain-derived neurotrophic factor, val66met, olfaction, odor identification, aging
HSV kategori
Forskningsprogram
psykologi
Identifikatorer
URN: urn:nbn:se:su:diva-47024DOI: 10.3389/fnagi.2010.00024PubMedID: PMC2893376OAI: oai:DiVA.org:su-47024DiVA, id: diva2:372674
Merknad

This work was supported by the Swedish Research Council Grant 421-2005-2113 to Maria Larsson and The Betula Study is funded by the Bank of Sweden Tercentenary Foundation (1988-0082:17), Swedish Council for Planning and Coordination of Research (D1988-0092, D1989-0115, D1990-0074, D1991-0258, D1992-0143, D1997-0756, D1997-1841, D1999-0739, B1999-474), Swedish Council for Research in the Humanities and Social Sciences (F377/1988-2000), the Swedish Council for Social Research (1988-1990: 88-0082, and 311/1991-2000), and the Swedish Research Council (315-2004-6977).

Tilgjengelig fra: 2010-11-26 Laget: 2010-11-26 Sist oppdatert: 2019-12-04bibliografisk kontrollert
Inngår i avhandling
1. Olfactory Function: The Influence of Demographic, Cognitive, and Genetic Factors
Åpne denne publikasjonen i ny fane eller vindu >>Olfactory Function: The Influence of Demographic, Cognitive, and Genetic Factors
2013 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Olfactory function is affected by demographic, cognitive, and genetic factors. In the present thesis, three empirical studies investigated individual differences in olfactory ability. Study I explored demographic and cognitive correlates in common olfactory tasks; odor detection, odor discrimination, and odor identification. The results indicated that old age influenced performance negatively in all tasks, and that semantic memory proficiency and executive functioning were related to odor discrimination and odor identification performance. No cognitive influence was observed for measurements of olfactory threshold. Using population-based data, Study II investigated a potential influence of the ApoE gene on olfactory identification after controlling for health status, semantic memory, and preclinical and clinical dementia. The main finding was that the ApoE- ɛ4 allele interacted with age, such that older ɛ4-carriers had an impaired odor identification performance relative to older non-carriers. Importantly, the negative ApoE- ɛ4 effect on olfactory proficiency was independent of clinical dementia conversion within five years. Study III investigated the effects of the BDNF val66met polymorphism on olfactory change over a five-year interval, in a community dwelling sample of young and old age cohorts. The results showed that age-related decline in olfactory identification was influenced by the BDNF val66met. In middle-aged subjects, no effect of BDNF val66met was observed although older val homozygote carriers showed a selectively larger olfactory decline than the older met carriers. Overall, results suggest that the relative influence of demographic and cognitive factors vary across different olfactory tasks and that two genes (ApoE and BDNF) impact age-related deficits in odor identification. Potential theoretical and practical implications of the findings are discussed as well as potential limitations of association studies in genomics research.

sted, utgiver, år, opplag, sider
Stockholm: Department of Psychology, Stockholm University, 2013. s. 80
Emneord
Olfaction, odor identification, odor threshold, odor discrimination, aging, gender, ApoE, BDNF, val66met, association study, population-based
HSV kategori
Forskningsprogram
psykologi
Identifikatorer
urn:nbn:se:su:diva-85907 (URN)978-91-7447-628-6 (ISBN)
Disputas
2013-02-15, David Magnussonsalen (U31), hus 8, Frescati Hagväg 8, Stockholm, 10:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2013-01-24 Laget: 2013-01-10 Sist oppdatert: 2013-01-24bibliografisk kontrollert

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