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Pittsburgh Compound-B and Alzheimer’s Disease Biomarkers in CSF, Plasma and Urine: An Exploratory Study
Department of Public Health/Geriatrics, Uppsala University.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 29, nr 3, s. 204-212Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PIB) is an in vivo ligand for measuring β-amyloid (Aβ) load. Associations between PET PIB and cerebrospinal fluid (CSF) Aβ1–42 and apolipoprotein E ε4 (APOE ε4) have been observed in several studies, but the relations between PIB uptake and other biomarkers of Alzheimer’s disease (AD) are less investigated. Method: PET PIB, PET 18Fluoro-2-deoxy-D-glucose and different AD biomarkers were measured twice in CSF, plasma and urine 12 months apart in 10 patients with a clinical diagnosis of mild to moderate AD. Results: PIB retention was constant over 1 year, inversely related to low CSF Aβ1–42 (p = 0.01) and correlated positively to the numbers of the APOE ε4 allele (0, 1 or 2) (p = 0.02). There was a relation between mean PIB retention and CSF ApoE protein (r = –0.59, p = 0.07), and plasma cystatin C (r = –0.56, p = 0.09). Conclusion: PIB retention is strongly related to CSF Aβ1–42, and to the numbers of the APOE ε4 allele.

sted, utgiver, år, opplag, sider
Basel: Karger AG , 2010. Vol. 29, nr 3, s. 204-212
Emneord [en]
Pittsburgh Compound-B, PET FDG, Alzheimer’s disease, follow-up, Biomarkers, CSF, Aβ1–42, Aβx-42 APOE, Cystatin C
HSV kategori
Forskningsprogram
psykologi
Identifikatorer
URN: urn:nbn:se:su:diva-47144DOI: 10.1159/000281832ISI: 000276783100003PubMedID: 20332638OAI: oai:DiVA.org:su-47144DiVA, id: diva2:373146
Merknad
authorCount :11Tilgjengelig fra: 2010-11-30 Laget: 2010-11-30 Sist oppdatert: 2022-02-24bibliografisk kontrollert

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