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Experience-dependent plasticity of white-matter microstructure extends into old age
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
Vise andre og tillknytning
2010 (engelsk)Inngår i: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 48, nr 13, 3878-3883 s.Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Experience-dependent alterations in the human brain's white-matter microstructure occur in early adulthood, but it is unknown whether such plasticity extends throughout life. We used cognitive training, diffusion-tensor imaging (DTI), and structural MRI to investigate plasticity of the white-matter tracts that connect the left and right hemisphere of the frontal lobes. Over a period of about 180 days, 20 younger adults and 12 older adults trained for a total of one hundred and one 1-h sessions on a set of three working memory, three episodic memory, and six perceptual speed tasks. Control groups were assessed at pre- and post-test. Training affected several DTI metrics and increased the area of the anterior part of the corpus callosum. These alterations were of similar magnitude in younger and older adults. The findings indicate that experience-dependent plasticity of white-matter microstructure extends into old age and that disruptions of structural interhemispheric connectivity in old age, which are pronounced in aging, are modifiable by experience and amenable to treatment.

sted, utgiver, år, opplag, sider
2010. Vol. 48, nr 13, 3878-3883 s.
Emneord [en]
Aging, Cognitive training, Plasticity, White-matter microstructure
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-74160DOI: 10.1016/j.neuropsychologia.2010.08.026OAI: oai:DiVA.org:su-74160DiVA: diva2:506907
Tilgjengelig fra: 2012-03-01 Laget: 2012-03-01 Sist oppdatert: 2017-12-07bibliografisk kontrollert

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