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pH-dependence of the specific binding of Cu(II) and Zn(II) ions to the amyloid-beta peptide
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.ORCID-id: 0000-0002-6048-6896
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
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2012 (engelsk)Inngår i: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 421, nr 3, s. 554-560Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Metal ions like Cu(II) and Zn(II) are accumulated in Alzheimer's disease amyloid plaques. The amyloid-beta (A beta) peptide involved in the disease interacts with these metal ions at neutral pH via ligands provided by the N-terminal histidines and the N-terminus. The present study uses high-resolution NMR spectroscopy to monitor the residue-specific interactions of Cu(II) and Zn(II) with N-15- and C-13,N-15-labeled A beta(1-40) peptides at varying pH levels. At pH 7.4 both ions bind to the specific ligands, competing with one another. At pH 5.5 Cu(II) retains its specific histidine ligands, while Zn(II) seems to lack residue-specific interactions. The low pH mimics acidosis which is linked to inflammatory processes in vivo. The results suggest that the cell toxic effects of redox active Cu(II) binding to AD may be reversed by the protective activity of non-redox active Zn(II) binding to the same major binding site under non-acidic conditions. Under acidic conditions, the protective effect of Zn(II) may be decreased or changed, since Zn(II) is less able to compete with Cu(II) for the specific binding site on the AD peptide under these conditions.

sted, utgiver, år, opplag, sider
2012. Vol. 421, nr 3, s. 554-560
Emneord [en]
Alzheimer's disease, Amyloid-beta peptide, NMR spectroscopy, Copper and zinc, Metal ions, Metal binding
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Identifikatorer
URN: urn:nbn:se:su:diva-80111DOI: 10.1016/j.bbrc.2012.04.043ISI: 000306152000026OAI: oai:DiVA.org:su-80111DiVA, id: diva2:553378
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AuthorCount:5;

Tilgjengelig fra: 2012-09-19 Laget: 2012-09-12 Sist oppdatert: 2022-02-24bibliografisk kontrollert

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Danielsson, JensWärmländer, SebastianGräslund, Astrid

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