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Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study
Vise andre og tillknytning
2010 (engelsk)Inngår i: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 21, nr 4, s. 1141-1151Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In this study, we analyzed differences in cortical thickness (CTH) between healthy controls (HC), subjects with stable mild cognitive impairment (S-MCI), progressive MCI (P-MCI), and Alzheimer's disease (AD), and assessed correlations between CHT and clinical disease severity, education, and apolipoprotein E4 (APOE) genotype. Automated CTH analysis was applied to baseline high-resolution structural MR images of 145 subjects with a maximum followup time of 7.4 years pooled from population-based study databases held in the University of Kuopio. Statistical differences in CTH between study groups and significant correlations between CTH and clinical and demographic factors were assessed and displayed on a cortical surface model. Compared to HC group (n = 26), the AD (n = 21) group displayed significantly reduced CTH in several areas of frontal and temporal cortices of the right hemisphere. Higher education and lower MMSE scores were correlated with reduced CTH in the AD group, whereas no significant correlation was found between CDR-SB scores or APOE genotype and CTH. The P-MCI group demonstrated significantly reduced CTH compared to S-MCI in frontal, temporal and parietal cortices even after statistically adjusting for all confounding variables. Ultimately, analysis of CTH can be used to detect cortical thinning in subjects with progressive MCI several years before conversion and clinical diagnosis of AD dementia, irrespective of their cognitive performance, education level, or APOE genotype.

sted, utgiver, år, opplag, sider
2010. Vol. 21, nr 4, s. 1141-1151
Emneord [en]
Alzheimer's disease, apolipoprotein E, cortical thickness, magnetic resonance imaging, mild cognitive impairment
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Identifikatorer
URN: urn:nbn:se:su:diva-85134DOI: 10.3233/JAD-2010-100114PubMedID: 21504134OAI: oai:DiVA.org:su-85134DiVA, id: diva2:585451
Tilgjengelig fra: 2013-01-10 Laget: 2013-01-07 Sist oppdatert: 2017-12-06bibliografisk kontrollert

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