Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Community Interactions Modify the Effects of Pharmaceutical Exposure: A Microcosm Study on Responses to Propranolol in Baltic Sea Coastal Organisms
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och botanik.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för tillämpad miljövetenskap (ITM).
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för analytisk kemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Vise andre og tillknytning
2014 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, nr 4, artikkel-id e93774Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

This study investigated the uptake and effects of a common human pharmaceutical, propranolol, on the structure and function of a coastal Baltic Sea model community consisting of macroalga (Ceramium tenuicorne), mussels (Mytilus edulis trossulus), amphipods (Gammarus spp.), water and sediment. The most sensitive species, the mussel, was affected to the same extent as in previous single species studies, while the effects on the amphipod and alga were smaller or even positive compared to experiments performed in less complex test systems. The observed cascade of beneficial effects was a result of inter-specific species interactions that buffered for more severe effects. The poor condition of the mussel led to a feeding shift from alga to mussel by the amphipods. The better food quality, due to the dietary shift, counteracted the effects of the exposure. Less amphipod grazing, together with increased levels of nutrients in the water was favourable for the alga, despite the negative effects of propranolol. This microcosm study showed effects on organisms on different organizational levels as well as interactions among the different components resulting in indirect exposure effects of both functional and structural nature. The combination of both direct and indirect effects would not have been detected using simpler single- or even two-species study designs. The observed structural changes would in the natural environment have a long-term influence on ecosystem function, especially in a low-biodiversity ecosystem like the Baltic Sea.

sted, utgiver, år, opplag, sider
2014. Vol. 9, nr 4, artikkel-id e93774
HSV kategori
Forskningsprogram
ekotoxikologi
Identifikatorer
URN: urn:nbn:se:su:diva-103957DOI: 10.1371/journal.pone.0093774ISI: 000334160900047OAI: oai:DiVA.org:su-103957DiVA, id: diva2:722879
Merknad

AuthorCount:5;

Tilgjengelig fra: 2014-06-09 Laget: 2014-05-27 Sist oppdatert: 2018-01-24bibliografisk kontrollert
Inngår i avhandling
1. Pharmaecological perspectives: Exposure studies using coastal Baltic Sea organisms
Åpne denne publikasjonen i ny fane eller vindu >>Pharmaecological perspectives: Exposure studies using coastal Baltic Sea organisms
2014 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

This thesis investigates the effects of pharmaceutical substances on coastal Baltic Sea organisms. Despite an increasing awareness of the occurrence of pharmaceuticals in various aquatic compartments, current knowledge of their possible effects on non-target organisms is limited. Especially scarce is the knowledge concerning possible long-term effects, mixture-effects, effects on non-standard test organisms and indirect effects from interactions among organisms. Also the environmental fate, availability and distribution of pharmaceuticals between sediment, water and biota is only rarely investigated.

The aim of this thesis was therefore to investigate the biological effects of pharmaceuticals, and their distribution in organisms of a coastal Baltic Sea community. In four studies, blue mussels, amphipods and macroalgae were exposed to pharmaceuticals in laboratory experiments. The effects from exposure, as well as recovery from the same, were studied on different physiological variables. With increasing complexity of experiment designs, the tested substances were found to affect aquatic organisms from different hierarchical levels both through direct negative effects, as well as through indirect positive effects within model communities. Moreover, the studies showed that the organisms were affected by exposure to environmentally relevant concentrations, but also that exposed organisms could recover from the exposure. Effects from pharmaceutical mixtures occurred in lower concentrations than effects from single pharmaceutical substances, and high internal concentrations of two pharmaceuticals – diclofenac and propranolol – were detected in exposed organisms.

The detected effects and the uptake of pharmaceuticals in biota demonstrate a possible problem for aquatic environments, but especially for the Baltic Sea, since this is a naturally sensitive ecosystem with low species diversity, low functional redundancy and a history of heavy pollution.

sted, utgiver, år, opplag, sider
Stockholm: Department of Ecology, Environment and Plant Sciences, Stockholm Univeristy, 2014. s. 58
Emneord
Pharmaceuticals, Baltic Sea, Mytilus edulis trossulus, Fucus vesiculosus, Ceramium tenuicorne, Gammarus spp., Direct effects, Inter-specific interactions
HSV kategori
Forskningsprogram
marin ekotoxikologi
Identifikatorer
urn:nbn:se:su:diva-101160 (URN)978-91-7447-871-6 (ISBN)
Disputas
2014-04-04, Nordenskiöldsalen, Geovetenskapens hus, Svante Arrhenius väg 12, Stockholm, 13:30 (engelsk)
Opponent
Veileder
Merknad

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 4: Manuscript.

Tilgjengelig fra: 2014-03-13 Laget: 2014-02-27 Sist oppdatert: 2016-05-06bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Søk i DiVA

Av forfatter/redaktør
Oskarsson, HannaWiklund, Ann-Kristin ErikssonThorsén, GunnarDanielsson, GabrielaKumblad, Linda
Av organisasjonen
I samme tidsskrift
PLoS ONE

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 162 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf