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The APOE epsilon 4 allele in relation to brain white-matter microstructure in adulthood and aging
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Umeå University, Sweden.
2014 (engelsk)Inngår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 55, nr 3, s. 263-267Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The Apolipoprotein E (ApoE) epsilon 4 allele is a major genetic risk factor for sporadic Alzheimer's disease and has been associated with structural and functional brain alterations across the adult life span. Recent studies have presented evidence that epsilon 4 affects microstructural properties of brain white matter (WM) in non-demented carriers of the epsilon 4 allele, but conflicting evidence has been presented as well. The main purpose of the present study was therefore to examine ApoE effects on WM in a large sample of middle-aged and older adults (N=273). Diffusion tensor imaging (DTI) data was acquired, and tract-based as well as voxel-wise analyses were conducted. The tract-based analyses revealed no significant ApoE effects, and no significant interactions between genotype and age were observed. Taken together, the findings of the present study suggest that ApoE effects on white-matter microstructure are less abundant than has been suggested in some previous studies.

sted, utgiver, år, opplag, sider
2014. Vol. 55, nr 3, s. 263-267
Emneord [en]
Brain, white matter, DTI, ApoE
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-106101DOI: 10.1111/sjop.12099ISI: 000337518200011OAI: oai:DiVA.org:su-106101DiVA, id: diva2:735334
Merknad

AuthorCount:2;

Tilgjengelig fra: 2014-07-25 Laget: 2014-07-21 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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