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Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
Vise andre og tillknytning
2015 (engelsk)Inngår i: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 10, nr 6, s. 843-853Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Mitochondria contain their own genetic system that provides subunits of the complexes driving oxidative phosphorylation. A quarter of the mitochondrial proteome participates in gene expression, but how all these factors are orchestrated and spatially organized is currently unknown. Here, we established a method to purify and analyze native and intact complexes of mitochondrial ribosomes. Quantitative mass spectrometry revealed extensive interactions of ribosomes with factors involved in all the steps of posttranscriptional gene expression. These interactions result in large expressosome-like assemblies that we termed mitochondrial organization of gene expression (MIOREX) complexes. Superresolution microscopy revealed that most MIOREX complexes are evenly distributed throughout the mitochondrial network, whereas a subset is present as nucleoid-MIOREX complexes that unite the whole spectrum of organellar gene expression. Our work therefore provides a conceptual framework for the spatial organization of mitochondrial protein synthesis that likely developed to facilitate gene expression in the organelle.

sted, utgiver, år, opplag, sider
2015. Vol. 10, nr 6, s. 843-853
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URN: urn:nbn:se:su:diva-115276DOI: 10.1016/j.celrep.2015.01.012ISI: 000349440200001OAI: oai:DiVA.org:su-115276DiVA, id: diva2:799813
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AuthorCount:8;

Tilgjengelig fra: 2015-03-31 Laget: 2015-03-18 Sist oppdatert: 2017-12-04bibliografisk kontrollert

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Kehrein, KirstenVargas Möller-Hergt, BraulioOtt, Martin
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