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Aging-related magnification of genetic effects on cognitive and brain integrity
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
Rekke forfattare: 32015 (engelsk)Inngår i: Trends in cognitive sciences, ISSN 1364-6613, E-ISSN 1879-307X, Vol. 19, nr 9, s. 506-514Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Heritability studies document substantial genetic influences on cognitive performance and decline in old age. Increasing evidence shows that effects of genetic variations on cognition, brain structure, and brain function become stronger as people age. Disproportionate impairments are typically observed for older individuals carrying disadvantageous genotypes of different candidate genes. These data support the resource-modulation hypothesis, which states that genetic effects are magnified in persons with constrained neural resources, such as older adults.,However, given that findings are not unequivocal, we discuss the need to address several factors that may resolve inconsistencies in the extant literature (gene-gene and gene-environment interactions, study populations, gene-environment correlations, and epigenetic mechanisms).

sted, utgiver, år, opplag, sider
2015. Vol. 19, nr 9, s. 506-514
Emneord [en]
aging, cognition, genetics, brain structure, brain function
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-121679DOI: 10.1016/j.tics.2015.06.008ISI: 000361165200008OAI: oai:DiVA.org:su-121679DiVA, id: diva2:889784
Tilgjengelig fra: 2015-12-28 Laget: 2015-10-13 Sist oppdatert: 2018-01-10bibliografisk kontrollert

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