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Multipotent versus differentiated cell fate selection in the developing Drosophila airways
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut. Stockholms universitet, Science for Life Laboratory (SciLifeLab). Justus Liebig University of Giessen, Germany.ORCID-id: 0000-0002-9153-6040
Rekke forfattare: 42015 (engelsk)Inngår i: eLIFE, E-ISSN 2050-084X, Vol. 4, artikkel-id e09646Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Developmental potentials of cells are tightly controlled at multiple levels. The embryonic Drosophila airway tree is roughly subdivided into two types of cells with distinct developmental potentials: a proximally located group of multipotent adult precursor cells (P-fate) and a distally located population of more differentiated cells (D-fate). We show that the GATA-family transcription factor (TF) Grain promotes the P-fate and the POU-homeobox TF Ventral veinless (Vvl/Drifter/U-turned) stimulates the D-fate. Hedgehog and receptor tyrosine kinase (RTK) signaling cooperate with Vvl to drive the D-fate at the expense of the P-fate while negative regulators of either of these signaling pathways ensure P-fate specification. Local concentrations of Decapentaplegic/BMP, Wingless/Wnt, and Hedgehog signals differentially regulate the expression of D-factors and P-factors to transform an equipotent primordial field into a concentric pattern of radially different morphogenetic potentials, which gradually gives rise to the distal-proximal organization of distinct cell types in the mature airway.

sted, utgiver, år, opplag, sider
2015. Vol. 4, artikkel-id e09646
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URN: urn:nbn:se:su:diva-130019DOI: 10.7554/eLife.09646ISI: 000373813200001OAI: oai:DiVA.org:su-130019DiVA, id: diva2:927051
Tilgjengelig fra: 2016-05-10 Laget: 2016-05-09 Sist oppdatert: 2022-03-23bibliografisk kontrollert

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