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Development of an interlaced-crossfiring geometry for proton grid therapy
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.ORCID-id: 0000-0002-4160-1078
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
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Antal upphovsmän: 6
2017 (Engelska)Ingår i: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 56, nr 11, 1437-1443 s.Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Grid therapy has in the past normally been performed with single field photon-beamgrids. In this work, we evaluated a method to deliver grid therapy based on interlacing and crossfiringgrids of mm-wide proton beamlets over a target volume, by Monte Carlo simulations.

Material and methods: Dose profiles for single mm-wide proton beamlets (1, 2 and 3 mm FWHM) inwater were simulated with the Monte Carlo code TOPAS. Thereafter, grids of proton beamlets weredirected toward a cubic target volume, located at the center of a water tank. The aim was to deliver anearly homogeneous dose to the target, while creating high dose heterogeneity in the normal tissue,i.e., high gradients between valley and peak doses in the grids, down to the close vicinity of thetarget.

Results: The relative increase of the beam width with depth was largest for the smallest beams(þ6.9mm for 1 mm wide and 150MeV proton beamlets). Satisfying dose coverage of the cubic targetvolume (r< ±5%) was obtained with the interlaced-crossfiring setup, while keeping the grid pattern ofthe dose distribution down to the target (valley-to-peak dose ratio<0.5 less than 1 cm before the tar-get). Center-to-center distances around 7–8 mm between the beams were found to give the best com-promise between target dose homogeneity and low peak doses outside of the target.

Conclusions: A nearly homogeneous dose distribution can be obtained in a target volume by crossfir-ing grids of mm-wide proton-beamlets, while maintaining the grid pattern of the dose distribution atlarge depths in the normal tissue, close to the target volume. We expect that the use of this methodwill increase the tumor control probability and improve the normal tissue sparing in grid therapy.

Ort, förlag, år, upplaga, sidor
2017. Vol. 56, nr 11, 1437-1443 s.
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URN: urn:nbn:se:su:diva-148188DOI: 10.1080/0284186X.2017.1350287OAI: oai:DiVA.org:su-148188DiVA: diva2:1150062
Tillgänglig från: 2017-10-17 Skapad: 2017-10-17 Senast uppdaterad: 2017-12-01Bibliografiskt granskad

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Thomas, HenryBassler, NielsUreba, AnaSiegbahn, Albert
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