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An actin-based nucleoskeleton involved in gene regulation and genome organization
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut. New York University Abu Dhabi (NYUAD), United Arab Emirates.
Antal upphovsmän: 22018 (Engelska)Ingår i: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 506, nr 2, s. 378-386Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In eukaryotic cells gene regulation is dependent on global genome organization. This is achieved, in response to favorable environmental conditions, through spatial redistribution of chromatin and changes in global epigenetic levels. This eventually drives movement of gene-rich chromatin loops and formation of DNA loops, consolidating neighborhoods of gene expression and silencing. One of the challenges for future work is to examine how these neighborhoods are formed and whether they host genes involved in the same cellular functions for sustained expression or silencing over time. In the present review, we summarize evidence that actin and actin-associated proteins regulate gene activity. Furthermore we discuss how these specific nuclear tasks in which actin is engaged are important to organize and consolidate the mammalian genome, ensuring gene activation and repression of gene programs important to establish cellular identity. We propose that these mechanisms are essential to control cellular development and differentiation.

Ort, förlag, år, upplaga, sidor
2018. Vol. 506, nr 2, s. 378-386
Nyckelord [en]
Nuclear actin, Nuclear myosin, Nucleoskeleton, Transcriptional regulation, Chromatin remodeling, Epigenetic modification, Genome organization, Differentiation
Nationell ämneskategori
Biologiska vetenskaper
Identifikatorer
URN: urn:nbn:se:su:diva-163618DOI: 10.1016/j.bbrc.2017.11.206ISI: 000452245500011PubMedID: 29203242OAI: oai:DiVA.org:su-163618DiVA, id: diva2:1276701
Tillgänglig från: 2019-01-08 Skapad: 2019-01-08 Senast uppdaterad: 2022-02-26Bibliografiskt granskad

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Percipalle, Piergiorgio

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Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Biochemical and Biophysical Research Communications - BBRC
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