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Modeling the spread of two successive SIR epidemics on a configuration model network
Stockholms universitet, Naturvetenskapliga fakulteten, Matematiska institutionen.
Stockholms universitet, Naturvetenskapliga fakulteten, Matematiska institutionen.
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Abstract [en]

We present a stochastic model for two successive SIR (Susceptible, Infectious, Recov-ered) epidemics in the same network structured population. Individuals infected duringthe first epidemic might have (partial) immunity for the second one. The first epidemic isanalysed through a bond percolation model, while the second epidemic is approximated bya three-type branching process in which the types of individuals depend on their position inthe percolation clusters used for the first epidemic. This branching process approximationenables us to calculate a threshold parameter and the probability of a large outbreak for thesecond epidemic.

We illustrate our results through two examples. In the first example individuals infectedby the first epidemic are independently either completely susceptible or completely immuneto the second epidemic. The probability of being completely immune is the same for allindividuals infected in the first epidemic. In the second example the recovered individual inthe first epidemic have reduced susceptibility and infectivity for the second epidemic.

Nyckelord [en]
Subsequent SIR epidemics, Reed-Frost model, Percolation, Multi-type branching processes
Nationell ämneskategori
Matematik
Forskningsämne
matematisk statistik
Identifikatorer
URN: urn:nbn:se:su:diva-167372OAI: oai:DiVA.org:su-167372DiVA, id: diva2:1299556
Tillgänglig från: 2019-03-27 Skapad: 2019-03-27 Senast uppdaterad: 2019-03-29Bibliografiskt granskad
Ingår i avhandling
1. Stochastic epidemics on random networks
Öppna denna publikation i ny flik eller fönster >>Stochastic epidemics on random networks
2019 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

This thesis considers stochastic epidemic models for the spread of epidemics in structured populations. The asymptotic behaviour of the models is analysed by using branching process approximations. The thesis contains four manuscripts.

Paper I is concerned with the study of the spread of sexually transmitted infections, or any other infectious diseases on a dynamic network. The model we investigate is about the spread of an SI (Susceptible → Infectious) type infectious disease in a population where partnerships are dynamic. We derive explicit formulas for the probability of extinction and the threshold parameter R0 using two branching process approximations for the model. In the first approximation some dependencies between infected individuals are ignored while the second branching process approximation is asymptotically exact and only defined if every individual in the population can have at most one partner at a time. By comparing the two approximations, we show that ignoring subtle dependencies in the dynamic epidemic model leads to wrong prediction of the probability of a large outbreak.

In paper II, we study a stochastic SIR (Susceptible → Infectious → Removed) epidemic model for the spread of an epidemic in populations structured through configuration model random graphs. We study the asymptotic (properly scaled) time until the end of an epidemic. This paper heavily relies on the theory of branching processes in continuous time.

In paper III, the effect of vaccination strategies on the duration of an epidemic in a large population is investigated. We consider three vaccination strategies: uniform vaccination, leaky vaccination and acquaintance vaccination.

In paper IV, we present a stochastic model for two successive SIR epidemics in the same network structured population. Individuals infected during the first epidemic might have (partial) immunity for the second one. The first epidemic is analysed through a bond percolation model, while the second epidemic is approximated by a three-type branching process in which the types of individuals depend on their status in the percolation clusters used for the analysis of the first epidemic. This branching process approximation enables us to calculate a threshold parameter and the probability of a large outbreak for the second epidemic. We use two special cases of acquired immunity for further evaluation.

Ort, förlag, år, upplaga, sidor
Stockholm: Department of Mathematics, Stockholm University, 2019
Nyckelord
Branching process, Configuration model, Random graph, Epidemic process, Final size, Threshold behaviour, Duration of an epidemic, Vaccination
Nationell ämneskategori
Matematik
Forskningsämne
matematisk statistik
Identifikatorer
urn:nbn:se:su:diva-167373 (URN)978-91-7797-661-5 (ISBN)978-91-7797-662-2 (ISBN)
Disputation
2019-05-16, sal 14, hus 5, Kräftriket, Roslagsvägen 101, Stockholm, 10:00 (Engelska)
Opponent
Handledare
Anmärkning

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 3: Manuscript. Paper 4: Manuscript.

Tillgänglig från: 2019-04-23 Skapad: 2019-03-27 Senast uppdaterad: 2020-05-18Bibliografiskt granskad

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