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Structural Patching Fosters Divergence of Mitochondrial Ribosomes
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Antal upphovsmän: 62019 (Engelska)Ingår i: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 36, nr 2, s. 207-219Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Mitochondrial ribosomes (mitoribosomes) are essential components of all mitochondria that synthesize proteins encoded by the mitochondrial genome. Unlike other ribosomes, mitoribosomes are highly variable across species. The basis for this diversity is not known. Here, we examine the composition and evolutionary history of mitoribosomes across the phylogenetic tree by combining three-dimensional structural information with a comparative analysis of the secondary structures of mitochondrial rRNAs (mt-rRNAs) and available proteomic data. We generate a map of the acquisition of structural variation and reconstruct the fundamental stages that shaped the evolution of the mitoribosomal large subunit and led to this diversity. Our analysis suggests a critical role for ablation and expansion of rapidly evolving mt-rRNA. These changes cause structural instabilities that are patched by the acquisition of pre-existing compensatory elements, thus providing opportunities for rapid evolution. This mechanism underlies the incorporation of mt-tRNA into the central protuberance of the mammalian mitoribosome, and the altered path of the polypeptide exit tunnel of the yeast mitoribosome. We propose that since the toolkits of elements utilized for structural patching differ between mitochondria of different species, it fosters the growing divergence of mitoribosomes.

Ort, förlag, år, upplaga, sidor
2019. Vol. 36, nr 2, s. 207-219
Nyckelord [en]
RNA evolution, RNA structure, ribosome, mitochondria, eukaryotes
Nationell ämneskategori
Biologiska vetenskaper
Identifikatorer
URN: urn:nbn:se:su:diva-167683DOI: 10.1093/molbev/msy221ISI: 000459328600001PubMedID: 30517740OAI: oai:DiVA.org:su-167683DiVA, id: diva2:1301817
Tillgänglig från: 2019-04-03 Skapad: 2019-04-03 Senast uppdaterad: 2019-04-03Bibliografiskt granskad

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Av författaren/redaktören
Brown, AlanAmunts, Alexey
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Institutionen för biokemi och biofysikScience for Life Laboratory (SciLifeLab)
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Molecular biology and evolution
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