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Forecasting the critical role of intermittent therapies for the control of bone resorption
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab). Comsats University Islamabad, Pakistan.ORCID-id: 0000-0003-0985-2712
Antal upphovsmän: 32019 (Engelska)Ingår i: Clinical Biomechanics, ISSN 0268-0033, E-ISSN 1879-1271, Vol. 68, s. 128-136Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Osteoporosis is a chronic metabolic disease characterized by an imbalance of bone resorption and formation, leading to bone fragility and increased susceptibility to fracture. Parathyroid hormone is approved therapy for the treatment of osteoporosis.

Methods: The intermittent therapy of parathyroid hormone requires accurate administration. Meta-analysis is conducted to draw a clear picture of the impact of intermittent therapy and dose rates relative to time, on the osteoporotic patients. A novel mathematical model is presented in this article synchronised with the parametric values, depicted from meta-analysis.

Findings: Results obtained from the mathematical model are in close agreement with the results obtained from the clinical trials. The model can be used to forecast the drug potency and dosage rates, to control the vicious cycle of osteoporosis.

Interpretations: The intermittent administration of parathyroid hormone, rather than the continuous administration, is more effective, furthermore it is also concluded that a mathematical model, linked with the extensive literature of clinical trials, using meta-analysis can help in drug administration and future clinical studies of drug development.

Ort, förlag, år, upplaga, sidor
2019. Vol. 68, s. 128-136
Nyckelord [en]
Biomechanics, Bone remodeling, Osteoporosis, Meta-analysis, Mathematical modeling
Nationell ämneskategori
Ortopedi Endokrinologi och diabetes
Identifikatorer
URN: urn:nbn:se:su:diva-175120DOI: 10.1016/j.clinbiomech.2019.04.023ISI: 000485852300018PubMedID: 31200297OAI: oai:DiVA.org:su-175120DiVA, id: diva2:1360897
Tillgänglig från: 2019-10-14 Skapad: 2019-10-14 Senast uppdaterad: 2022-02-17Bibliografiskt granskad

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Javed, Sana

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Institutionen för biokemi och biofysikScience for Life Laboratory (SciLifeLab)
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OrtopediEndokrinologi och diabetes

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