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Probing segmental order in lipid bilayers at variable hydration levels by amplitude- and phase-modulated cross-polarization NMR
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi.
2005 Ingår i: Phys. Chem. Chem. Phys., Vol. 7, s. 3255-3257Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
2005. Vol. 7, s. 3255-3257
Identifikatorer
URN: urn:nbn:se:su:diva-25063OAI: oai:DiVA.org:su-25063DiVA, id: diva2:198822
Anmärkning
Part of urn:nbn:se:su:diva-7681Tillgänglig från: 2008-05-13 Skapad: 2008-05-13Bibliografiskt granskad
Ingår i avhandling
1. Solid-State NMR Characterization of Lipid Membranes
Öppna denna publikation i ny flik eller fönster >>Solid-State NMR Characterization of Lipid Membranes
2008 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

This thesis deals with the study of lipid bilayer systems by solid-state nuclear magnetic resonance. Two-dimensional 1H-13C separated local field experiments under magic-angle spinning were employed to investigate structural and dynamical modifications of cell membranes, resulting from the addition of compounds with some biological relevance. For further interpretation of the segmental order obtained from the 2D experiments other methods, such as 31P-NMR, 2H-NMR and molecular dynamics simulations, were also employed.

The work presented in this thesis can be divided into two parts. The first part refers to the setup of experimental conditions. Heating and hydration effects were addressed in order to define both the temperature of the system as well as the number of water molecules per lipid necessary to fully hydrate the bilayer. Application of this experimental setup to lipid membrane systems with biological relevance constitutes the second part. The interaction of monogalactosyl- diacylglycerol, the most abundant lipid on earth, with dimyristoylphosphatidylcholine, was studied, which resulted in a frustrated bilayer. Furthermore, small molecules of local anesthetics, with focus on lidocaine, were inserted in the model membrane with the purpose of understanding the influence of local anesthetics on lipid bilayers.

Ort, förlag, år, upplaga, sidor
Stockholm: Institutionen för fysikalisk kemi, oorganisk kemi och strukturkemi, 2008. s. 69
Nyckelord
Solid-State NMR, Membranes, Lipids, Glycolipids, Local Anesthetics, Hydration
Nationell ämneskategori
Fysikalisk kemi
Forskningsämne
fysikalisk kemi
Identifikatorer
urn:nbn:se:su:diva-7681 (URN)978-91-7155-659-2 (ISBN)
Disputation
2008-06-03, Magnélisalen, Kemiska övningslaboratoriet, Svante Arrhenius väg 12 A, Stockholm, 13:00
Opponent
Handledare
Tillgänglig från: 2008-05-13 Skapad: 2008-05-13Bibliografiskt granskad

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