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Dynode-Timing Method for PET Block Detectors
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum. (Siemens Molecular Imaging)
(Siemens Molecular Imaging)
(Siemens Molecular Imaging)
Visa övriga samt affilieringar
2008 (Engelska)Ingår i: IEEE Transactions on Nuclear Science, ISSN 0018-9499, E-ISSN 1558-1578, Vol. 55, nr 1, s. 451-456Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The focus of this paper is the investigation of a new dynode-timing technique optimized for PET block detectors. This method allows utilization of dynode signals from single but especially multiple photo-multiplier tubes (PMTs), operated with negative high-voltage. The technique will provide an event-timing trigger without deteriorating the anode signal. A printed circuit board has been developed and built for this investigation. Benchmark measurements have been performed, comparing timing of the anode signal with timing of the inverted last-dynode signal and timing of the dynode signal extracted via a newly developed LVPECL-logic based board. Timing measurements were performed with plastic as well as LSO scintillators. From single PMT measurements we find a 30 ps improvement with the dynode-timing method compared to the standard anode timing with two Photonis XP2020Q PMTs with LSO (10 mmtimes10 mmtimes10 mm). For a quad-PMT block detector, assembled of four Hamamatsu R9800 with a Hi-Rez block, the timing-resolution improves ~10%, by 43 ps compared to the standard anode timing.

Ort, förlag, år, upplaga, sidor
2008. Vol. 55, nr 1, s. 451-456
Identifikatorer
URN: urn:nbn:se:su:diva-31664ISI: 000253224800001OAI: oai:DiVA.org:su-31664DiVA, id: diva2:278543
Tillgänglig från: 2009-11-26 Skapad: 2009-11-23 Senast uppdaterad: 2017-12-12Bibliografiskt granskad
Ingår i avhandling
1. Detector Considerations for Time-of-Flight in Positron Emission Tomography
Öppna denna publikation i ny flik eller fönster >>Detector Considerations for Time-of-Flight in Positron Emission Tomography
2009 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Positron-Emission-Tomography (PET) is a modern imaging technique in nuclear medicine providing quantitative 3D distribution of a radioactive tracer substance in the human body. The gamma-detector is the first link in the chain of components that constitutes a PET. It converts incoming radiation into optical light pulses, which are detected by photo multiplier tubes. Here the light is converted into electric pulses, to be further processed by the acquisition electronics. Improving detector sensitivity and resolution is of great value in research and in clinical practice.

The focus of this work is to improve the detector to give it time-of-flight (TOF) capabilities, in order to further improve sensitivity, which in turn leads to increased image quality, faster scan time and/or reduced dose exposure for the patient.

Image quality has improved over the years, but losses in image quality have been reported for heavy patients, due to increased attenuation, and more dispersed counts over a larger volume. Instrumentation limits are still significant in heavy patient images, but the incorporation of TOF information promises to alleviate some of the limitations.

In order to improve the timing resolution of the detector fast photo-multipliers and a novel scheme to extract the event timing trigger from a detector by using the summed dynode signal were investigated.

When designing new PET detectors, it is important to have detailed understanding and control of the light sharing mechanisms in the crystal arrays. Therefore it was necessary to perform optical simulations and single crystal light output measurements to derive a model for an LSO block detector.

Another way to improve the image quality is to use the depth-of-interaction (DOI) of the gamma ray within the detector. It is shown that a multi-layer phoswich detector comprised of LSO with different decay times and TOF capability, combines the benefits of TOF and DOI in one detector, maximizing the effective sensitivity gain.

Ort, förlag, år, upplaga, sidor
Stockholm: Department of Physics, Stockholm University, 2009. s. 78
Nyckelord
Positron Emission Tomography, Time of Flight, Depth of Interaction, LSO
Nationell ämneskategori
Radiologi och bildbehandling
Forskningsämne
medicinsk strålningsfysik
Identifikatorer
urn:nbn:se:su:diva-31587 (URN)978-91-7155-979-1 (ISBN)
Disputation
2010-01-08, FB52, AlbaNova universitetscentrum, Roslagstullsbacken 21, Stockholm, 10:00 (Engelska)
Opponent
Handledare
Anmärkning
At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 7: Submitted. Tillgänglig från: 2009-12-03 Skapad: 2009-11-19 Senast uppdaterad: 2009-12-22Bibliografiskt granskad

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