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Sesquiterpenoid unsaturated dialdehydes increase the concentration of intracellular free Ca2+ in human neuroblastoma SH-SY5Y cells.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.ORCID-id: 0000-0001-6298-201X
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
1994 (Engelska)Ingår i: Natural toxins (Print), ISSN 1056-9014, E-ISSN 1522-7189, Vol. 2, nr 2, s. 89-95Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The effect of the three sesquiterpenoid unsaturated dialdehydes--polygodial, isovelleral, and epipolygodial--on intracellular free Ca2+ concentration, [Ca2+]i, was investigated in the human neuroblastoma cell line SH-SY5Y. [Ca2+]i was measured by the Fura-2 spectrophotofluorometric technique in multi-cell and single-cell experiments. Polygodial and isovelleral induced an increase in [Ca2+]i at low concentrations (0.1 and 0.5 micrograms/ml, respectively) but epipolygodial affected [Ca2+]i only at a high concentration (10 micrograms/ml). The results indicated that there was a relationship between the effect on [Ca2+]i and the pungency of the sesquiterpenes tested. Experiments in a Ca(2+)-free extracellular solution showed that Ca2+ was also released from intracellular calcium stores. Images from single-cell experiments indicated that polygodial induced fluctuations in the [Ca2+]i in some cells. The mechanism behind the sesquiterpene induced increase of the [Ca2+]i was not identified but a possible mobilization of inositol phosphates is considered.

Ort, förlag, år, upplaga, sidor
1994. Vol. 2, nr 2, s. 89-95
Nyckelord [en]
Polygodial, Isovelleral, Epipolygodial
Identifikatorer
URN: urn:nbn:se:su:diva-32630PubMedID: 8075898OAI: oai:DiVA.org:su-32630DiVA, id: diva2:281141
Tillgänglig från: 2009-12-14 Skapad: 2009-12-14 Senast uppdaterad: 2017-12-12Bibliografiskt granskad

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