Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Age-Related Olfactory Decline is Associated with the BDNF Val66met Polymorphism: Evidence from a Population-Based Study
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Kognitiv psykologi.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.ORCID-id: 0000-0002-0856-0569
Department of Pharmacology, Göteborg University, Göteborg, Sweden.
Visa övriga samt affilieringar
2010 (Engelska)Ingår i: Frontiers in Aging Neuroscience, ISSN 1663-4365, Vol. 2, nr 7, s. 24-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The present study investigates the effect of the brain-derived neurotrophic factor (BDNF) val66met polymorphism on change in olfactory function in a large scale, longitudinal population-based sample (n = 836). The subjects were tested on a 13 item force-choice odor identification test on two test occasions over a 5-year-interval. Sex, education, health-related factors, and semantic ability were controlled for in the statistical analyses. Results showed an interaction effect of age and BDNF val66met on olfactory change, such that the magnitude of olfactory decline in the older age cohort (70–90years old at baseline) was larger for the val homozygote carriers than for the met carriers. The older met carriers did not display larger age-related decline in olfactory function compared to the younger group. The BDNF val66met polymorphism did not affect the rate of decline in the younger age cohort (45–65years). The findings are discussed in the light of the proposed roles of BDNF in neural development and maintenance.

Ort, förlag, år, upplaga, sidor
2010. Vol. 2, nr 7, s. 24-
Nyckelord [en]
brain-derived neurotrophic factor, val66met, olfaction, odor identification, aging
Nationell ämneskategori
Psykologi
Forskningsämne
psykologi
Identifikatorer
URN: urn:nbn:se:su:diva-47024DOI: 10.3389/fnagi.2010.00024PubMedID: PMC2893376OAI: oai:DiVA.org:su-47024DiVA, id: diva2:372674
Anmärkning

This work was supported by the Swedish Research Council Grant 421-2005-2113 to Maria Larsson and The Betula Study is funded by the Bank of Sweden Tercentenary Foundation (1988-0082:17), Swedish Council for Planning and Coordination of Research (D1988-0092, D1989-0115, D1990-0074, D1991-0258, D1992-0143, D1997-0756, D1997-1841, D1999-0739, B1999-474), Swedish Council for Research in the Humanities and Social Sciences (F377/1988-2000), the Swedish Council for Social Research (1988-1990: 88-0082, and 311/1991-2000), and the Swedish Research Council (315-2004-6977).

Tillgänglig från: 2010-11-26 Skapad: 2010-11-26 Senast uppdaterad: 2019-12-04Bibliografiskt granskad
Ingår i avhandling
1. Olfactory Function: The Influence of Demographic, Cognitive, and Genetic Factors
Öppna denna publikation i ny flik eller fönster >>Olfactory Function: The Influence of Demographic, Cognitive, and Genetic Factors
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Olfactory function is affected by demographic, cognitive, and genetic factors. In the present thesis, three empirical studies investigated individual differences in olfactory ability. Study I explored demographic and cognitive correlates in common olfactory tasks; odor detection, odor discrimination, and odor identification. The results indicated that old age influenced performance negatively in all tasks, and that semantic memory proficiency and executive functioning were related to odor discrimination and odor identification performance. No cognitive influence was observed for measurements of olfactory threshold. Using population-based data, Study II investigated a potential influence of the ApoE gene on olfactory identification after controlling for health status, semantic memory, and preclinical and clinical dementia. The main finding was that the ApoE- ɛ4 allele interacted with age, such that older ɛ4-carriers had an impaired odor identification performance relative to older non-carriers. Importantly, the negative ApoE- ɛ4 effect on olfactory proficiency was independent of clinical dementia conversion within five years. Study III investigated the effects of the BDNF val66met polymorphism on olfactory change over a five-year interval, in a community dwelling sample of young and old age cohorts. The results showed that age-related decline in olfactory identification was influenced by the BDNF val66met. In middle-aged subjects, no effect of BDNF val66met was observed although older val homozygote carriers showed a selectively larger olfactory decline than the older met carriers. Overall, results suggest that the relative influence of demographic and cognitive factors vary across different olfactory tasks and that two genes (ApoE and BDNF) impact age-related deficits in odor identification. Potential theoretical and practical implications of the findings are discussed as well as potential limitations of association studies in genomics research.

Ort, förlag, år, upplaga, sidor
Stockholm: Department of Psychology, Stockholm University, 2013. s. 80
Nyckelord
Olfaction, odor identification, odor threshold, odor discrimination, aging, gender, ApoE, BDNF, val66met, association study, population-based
Nationell ämneskategori
Psykologi (exklusive tillämpad psykologi)
Forskningsämne
psykologi
Identifikatorer
urn:nbn:se:su:diva-85907 (URN)978-91-7447-628-6 (ISBN)
Disputation
2013-02-15, David Magnussonsalen (U31), hus 8, Frescati Hagväg 8, Stockholm, 10:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2013-01-24 Skapad: 2013-01-10 Senast uppdaterad: 2013-01-24Bibliografiskt granskad

Open Access i DiVA

Fulltext(496 kB)178 nedladdningar
Filinformation
Filnamn FULLTEXT02.pdfFilstorlek 496 kBChecksumma SHA-512
ec1550efcbad59895b269c5c19c150757d19d3524a5814bee0356c7eb333b8b79e83e02753a96a92669f9d32af47e6ab786053e9f0027ddfdc8a173a9cb1589f
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Hedner, MargaretaNilsson, Lars-GöranOlofsson, Jonas K.Larsson, Maria
Av organisationen
Perception och psykofysikKognitiv psykologi
Psykologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 178 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 439 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf