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A graphic user interface toolkit for specification, report and comparison of dose-response relations and treatment plans using the biologically effective uniform dose
Stockholms universitet, Naturvetenskapliga fakulteten, Medicinsk strålningsfysik (tills m KI).
Visa övriga samt affilieringar
2010 (Engelska)Ingår i: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 100, nr 1, 69-78 s.Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A toolkit (BEUDcal) has been developed for evaluating the effectiveness and for predicting the outcome of treatment plans by calculating the biologically effective uniform dose (BEUD) and complication-free tumor control probability. The input for the BEUDcal is the differential dose-volume histograms of organs exported from the treatment planning system. A clinical database is built for the dose-response parameters of different tumors and normal tissues. Dose-response probabilities of all the examined organs are illustrated together with the corresponding BEUDs and the P+ values. Furthermore, BEUDcal is able to generate a report that simultaneously presents the radiobiological evaluation together with the physical dose indices, showing the complementary relation between the physical and radiobiological treatment plan analysis performed by BEUDcal. Comparisons between treatment plans for helical tomotherapy and multileaf collimator-based intensity modulated radiotherapy of a lung patient were demonstrated to show the versatility of BEUDcal in the assessment and report of dose-response relations.

Ort, förlag, år, upplaga, sidor
2010. Vol. 100, nr 1, 69-78 s.
Nyckelord [en]
Biologically effective uniform dose, Helical tomotherapy, Treatment planning, Radiobiological objectives
Nationell ämneskategori
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:su:diva-51752DOI: 10.1016/j.cmpb.2010.02.003ISI: 000282391500007OAI: oai:DiVA.org:su-51752DiVA: diva2:386033
Anmärkning
authorCount :5Tillgänglig från: 2011-01-12 Skapad: 2011-01-12 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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Computer Methods and Programs in Biomedicine
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