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Odor identification impairment in carriers of ApoE-epsilon 4 is independent of clinical dementia
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.ORCID-id: 0000-0002-0856-0569
Umeå universitet.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.ORCID-id: 0000-0003-4531-4313
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.
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2010 (Engelska)Ingår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 31, nr 4, s. 567-577Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The ApoE acme is expressed in olfactory brain structures and is believed to play a role in neuronal regenerative processes as well as in development of Alzheimer's disease (AD), the most common form of dementia The epsilon 4 allele lots been reported to be associated with compromised odor identification ability in the elderly, and this deficit has been interpreted as a sign of pre-diagnostic AD However, because it has not been demonstrated that the relationship between the epsilon 4 allele and odor identification is mediated by dementia, it is possible that the epsilon 4 allele may have an effect on odor identification over and above any effects of dementia. The present study investigated effects of ApoE-status on odor identification in a lame, population-based sample (n =1236) of adults (45-80 years), who were assessed for dementia at time of testing and 5 years later The results showed that the epsilon 4 allele was associated with an odor identification deficit among, elderly participants (75-80) Critically. this effect remained after current and pre-diagnostic dementia, vocabulary, global cognitive status and health variables were partialled out The present results suggest that the ApoE gene plays a role in olfactory functioning that is independent of dementia conversion within 5 years

Ort, förlag, år, upplaga, sidor
2010. Vol. 31, nr 4, s. 567-577
Nyckelord [en]
ApoE, Odor identification, Olfaction, Aging, Alzheimer's disease
Nationell ämneskategori
Psykologi
Identifikatorer
URN: urn:nbn:se:su:diva-52206DOI: 10.1016/j.neurobiolaging.2008.05.019ISI: 000276759700005OAI: oai:DiVA.org:su-52206DiVA, id: diva2:387426
Anmärkning

The Betula Study is funded by the Bank of Sweden Tercentenary Foundation (1988-0082:17), Swedish Council for Planning and Coordination of Research (D1988-0092, D1989-0115, D1990-0074, D1991-0258, D1992-0143, D1997-0756, D1997-1841, D1999-0739 and B1999-474), Swedish Council for Research in the Humanities and Social Sciences (F377/1988–2000), and the Swedish Council for Social Research (1988–1990: 88-0082 and 311/1991–2000). The authors acknowledge the contribution to this paper of the VIB—Department of Molecular Genetics at the University of Antwerp, Antwerpen, Belgium, and Rolf Adolfsson at the Department of Psychiatry, Umeå University, to the APOE genotyping of Betula individuals. Also, the authors thank Birgitta Törnkvist at the Department of Statistics, Umeå University, for valuable consultation, and six anonymous reviewers for helpful comments. authorCount :6

Tillgänglig från: 2011-01-14 Skapad: 2011-01-13 Senast uppdaterad: 2020-02-20Bibliografiskt granskad
Ingår i avhandling
1. Olfactory Function: The Influence of Demographic, Cognitive, and Genetic Factors
Öppna denna publikation i ny flik eller fönster >>Olfactory Function: The Influence of Demographic, Cognitive, and Genetic Factors
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Olfactory function is affected by demographic, cognitive, and genetic factors. In the present thesis, three empirical studies investigated individual differences in olfactory ability. Study I explored demographic and cognitive correlates in common olfactory tasks; odor detection, odor discrimination, and odor identification. The results indicated that old age influenced performance negatively in all tasks, and that semantic memory proficiency and executive functioning were related to odor discrimination and odor identification performance. No cognitive influence was observed for measurements of olfactory threshold. Using population-based data, Study II investigated a potential influence of the ApoE gene on olfactory identification after controlling for health status, semantic memory, and preclinical and clinical dementia. The main finding was that the ApoE- ɛ4 allele interacted with age, such that older ɛ4-carriers had an impaired odor identification performance relative to older non-carriers. Importantly, the negative ApoE- ɛ4 effect on olfactory proficiency was independent of clinical dementia conversion within five years. Study III investigated the effects of the BDNF val66met polymorphism on olfactory change over a five-year interval, in a community dwelling sample of young and old age cohorts. The results showed that age-related decline in olfactory identification was influenced by the BDNF val66met. In middle-aged subjects, no effect of BDNF val66met was observed although older val homozygote carriers showed a selectively larger olfactory decline than the older met carriers. Overall, results suggest that the relative influence of demographic and cognitive factors vary across different olfactory tasks and that two genes (ApoE and BDNF) impact age-related deficits in odor identification. Potential theoretical and practical implications of the findings are discussed as well as potential limitations of association studies in genomics research.

Ort, förlag, år, upplaga, sidor
Stockholm: Department of Psychology, Stockholm University, 2013. s. 80
Nyckelord
Olfaction, odor identification, odor threshold, odor discrimination, aging, gender, ApoE, BDNF, val66met, association study, population-based
Nationell ämneskategori
Psykologi (exklusive tillämpad psykologi)
Forskningsämne
psykologi
Identifikatorer
urn:nbn:se:su:diva-85907 (URN)978-91-7447-628-6 (ISBN)
Disputation
2013-02-15, David Magnussonsalen (U31), hus 8, Frescati Hagväg 8, Stockholm, 10:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2013-01-24 Skapad: 2013-01-10 Senast uppdaterad: 2013-01-24Bibliografiskt granskad

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Olofsson, Jonas K.Wiens, StefanHedner, MargaretaNilsson, Lars-GöranLarsson, Maria
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Perception och psykofysikKognitiv psykologi
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