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Dietary Acrylamide Intake during Pregnancy and Fetal Growth-Results from the Norwegian Mother and Child Cohort Study (MoBa)
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK), Avdelningen för miljökemi.
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2013 (Engelska)Ingår i: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 121, nr 3, s. 374-379Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans. OBJECTIVES: We assessed associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birth weight. METHODS: This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ), which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n = 79). Data on infant birth weight and gestational age were obtained from the Medical Birth Registry of Norway. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes. RESULTS: Acrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95% CI: 1.02, 1.21) and the coefficient for birth weight was -25.7 g (95% CI: -35.9, -15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide-and glycidamide-Hb adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95% CI: 0.02, 0.44; and 0.48; 95% CI: 0.29, 0.63, respectively). CONCLUSIONS: Lowering dietary acrylamide intake during pregnancy may improve fetal growth.

Ort, förlag, år, upplaga, sidor
2013. Vol. 121, nr 3, s. 374-379
Nyckelord [en]
acrylamide, birth weight, diet, Hb adducts, MoBa, pregnancy, small for gestational age
Nationell ämneskategori
Arbetsmedicin och miljömedicin Ekologi Miljövetenskap Farmakologi och toxikologi
Identifikatorer
URN: urn:nbn:se:su:diva-94194DOI: 10.1289/ehp.1205396ISI: 000323703500030OAI: oai:DiVA.org:su-94194DiVA, id: diva2:652452
Anmärkning

AuthorCount:12

Funding Agencies:

Norwegian Ministry of Health; Ministry of Education and Research, National Institutes of Health (NIH)/National Institute of Environmental Health Sciences  NO1-75558; NIH/National Institute of Neurological Disorders and Stroke  1 UO1 NS 047537-01;  Norwegian Research Council/FUGE  151918/S10;  EU  FOOD-CT-2005-016320;  Swedish Cancer and Allergy Foundation;   Swedish Research Council Formas 

Tillgänglig från: 2013-09-30 Skapad: 2013-09-30 Senast uppdaterad: 2018-01-11Bibliografiskt granskad

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von Stedingk, HansRydberg, PerTörnqvist, Margareta
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Journal of Environmental Health Perspectives
Arbetsmedicin och miljömedicinEkologiMiljövetenskapFarmakologi och toxikologi

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