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Linear energy transfer painting with proton therapy: a means of reducing radiation doses with equivalent clinical effectiveness
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum. University of Pennsylvania, Philadelphia.
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum. Karolinska Institutet, Sweden.ORCID-id: 0000-0002-7101-240X
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2015 (Engelska)Ingår i: International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, E-ISSN 1879-355X, Vol. 91, nr 5, 1057-1064 s.Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer (LETd) while keeping the radiobiologically weighted dose (DRBE) to the target the same.

Methods and Materials: The target is painted with LETd by using 2, 4, and 7 fields aimed at the proximal segment of the target (split target planning [STP]). As the LETd within the target increases with increasing number of fields, D decreases to maintain the DRBE the same as the conventional treatment planning method by using beams treating the full target (full target planning [FTP]).

Results: The LETd increased 61% for 2-field STP (2STP) compared to FTP, 72% for 4STP, and 82% for 7STP inside the target. This increase in LETd led to a decrease of D with 5.3 ± 0.6 Gy for 2STP, 4.4 ± 0.7 Gy for 4STP, and 5.3 ± 1.1 Gy for 7STP, keeping the DRBE at 90% of the volume (DRBE, 90) constant to FTP.

Conclusions: LETd painting offers a method to reduce prescribed dose at no cost to the biological effectiveness of the treatment.

Ort, förlag, år, upplaga, sidor
2015. Vol. 91, nr 5, 1057-1064 s.
Nationell ämneskategori
Cancer och onkologi
Forskningsämne
medicinsk strålningsfysik; onkologi; radiofysik
Identifikatorer
URN: urn:nbn:se:su:diva-111167DOI: 10.1016/j.ijrobp.2014.12.049ISI: 000351734000024OAI: oai:DiVA.org:su-111167DiVA: diva2:774552
Tillgänglig från: 2014-12-25 Skapad: 2014-12-25 Senast uppdaterad: 2017-12-05Bibliografiskt granskad

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