Widespread episodic thiamine deficiency in Northern Hemisphere wildlifeVisa övriga samt affilieringar
Antal upphovsmän: 212016 (Engelska)Ingår i: Scientific Reports, E-ISSN 2045-2322, Vol. 6, artikel-id 38821Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Many wildlife populations are declining at rates higher than can be explained by known threats to biodiversity. Recently, thiamine (vitamin B-1) deficiency has emerged as a possible contributing cause. Here, thiamine status was systematically investigated in three animal classes: bivalves, ray-finned fishes, and birds. Thiamine diphosphate is required as a cofactor in at least five life-sustaining enzymes that are required for basic cellular metabolism. Analysis of different phosphorylated forms of thiamine, as well as of activities and amount of holoenzyme and apoenzyme forms of thiaminedependent enzymes, revealed episodically occurring thiamine deficiency in all three animal classes. These biochemical effects were also linked to secondary effects on growth, condition, liver size, blood chemistry and composition, histopathology, swimming behaviour and endurance, parasite infestation, and reproduction. It is unlikely that the thiamine deficiency is caused by impaired phosphorylation within the cells. Rather, the results point towards insufficient amounts of thiamine in the food. By investigating a large geographic area, by extending the focus from lethal to sublethal thiamine deficiency, and by linking biochemical alterations to secondary effects, we demonstrate that the problem of thiamine deficiency is considerably more widespread and severe than previously reported.
Ort, förlag, år, upplaga, sidor
2016. Vol. 6, artikel-id 38821
Nationell ämneskategori
Annan geovetenskap och miljövetenskap
Identifikatorer
URN: urn:nbn:se:su:diva-137564DOI: 10.1038/srep38821ISI: 000389688300001PubMedID: 27958327Scopus ID: 2-s2.0-85006010412OAI: oai:DiVA.org:su-137564DiVA, id: diva2:1064184
2017-01-122017-01-092022-09-15Bibliografiskt granskad