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Role of inflammation in Human Fatigue: Relevance of Multidimensional Assessments and Potential Neuronal Mechanisms
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Karolinska Institutet, Sweden.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Biologisk psykologi. Karolinska Institutet, Sweden.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Karolinska Institutet, Sweden; University Hospital Essen, Germany.
Rekke forfattare: 32017 (engelsk)Inngår i: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 8, artikkel-id 21Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Fatigue is a highly disabling symptom in various medical conditions. While inflammation has been suggested as a potential contributor to the development of fatigue, underlying mechanisms remain poorly understood. In this review, we propose that a better assessment of central fatigue, taking into account its multidimensional features, could help elucidate the role and mechanisms of inflammation in fatigue development. A description of the features of central fatigue is provided, and the current evidence describing the association between inflammation and fatigue in various medical conditions is reviewed. Additionally, the effect of inflammation on specific neuronal processes that may be involved in distinct fatigue dimensions is described. We suggest that the multidimensional aspects of fatigue should be assessed in future studies of inflammation-induced fatigue and that this would benefit the development of effective therapeutic interventions.

sted, utgiver, år, opplag, sider
2017. Vol. 8, artikkel-id 21
Emneord [en]
central fatigue, inflammation, immune system, multidimensional assessments, motivation, ventral striatum, anterior cingulate cortex, insula
HSV kategori
Forskningsprogram
psykologi
Identifikatorer
URN: urn:nbn:se:su:diva-140322DOI: 10.3389/fimmu.2017.00021ISI: 000392330000001PubMedID: 28163706OAI: oai:DiVA.org:su-140322DiVA, id: diva2:1079182
Tilgjengelig fra: 2017-03-07 Laget: 2017-03-07 Sist oppdatert: 2018-01-14bibliografisk kontrollert

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