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RADIATION-INDUCED CHANGES IN LEVELS OF SELECTED PROTEINS IN PERIPHERAL BLOOD SERUM OF BREAST CANCER PATIENTS AS A POTENTIAL TRIAGE BIODOSIMETER FOR LARGE-SCALE RADIOLOGICAL EMERGENCIES
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. Institute of Mother and Child, Poland.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. University of Latvia, Latvia.
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Number of Authors: 112014 (English)In: Health Physics, ISSN 0017-9078, E-ISSN 1538-5159, Vol. 107, no 6, p. 555-563Article in journal (Refereed) Published
Abstract [en]

The threat of a large scale radiological emergency, where thousands of people may require fast biological dosimetry for the purpose of triage, makes it necessary to search for new, high throughput biological dosimeters. The authors tested an assay based on the quantitative analysis of selected proteins in peripheral blood serum. They were particularly interested in testing proteins that are specific to irradiation of skin, as these can be used in cases of partial body exposure. Candidate proteins were identified in an earlier study with mice, where skin of the animals was exposed to different doses of radiation and global expression of serum proteins was analyzed. Eight proteins were found, the expression of which showed a consistent dose-response relationship. Human analogues of these proteins were identified, and their expression was measured in peripheral blood serum of 16 breast cancer patients undergoing external beam radiotherapy. The proteins were Apolipoprotein E; Apolipoprotein H; Complement protein 7; Prothrombinase; Pantothenate Kinase 4; Alpha-2-macroglobulin; Fetuin B and Alpha-1-Anti-Chymotrypsin. Measurements were carried out in blood samples collected prior to exposure (control), on the day after one fraction (2 Gy), on the day after five fractions (10 Gy), on the day after 10 fractions (20 Gy), and 1 mo after 23-25 fractions (total dose of 46-50 Gy). Multivariate analysis was carried out, and a multinomial logistic regression model was built. The results indicate that the combined analysis of Apolipoprotein E, Factor X, and Pantothenate Kinase 4 allows discriminating between exposure to 2 Gy and lower and between 10 Gy and higher. The discrimination is possible up to 1 mo after exposure.

Place, publisher, year, edition, pages
2014. Vol. 107, no 6, p. 555-563
Keywords [en]
accidents, handling, biological indicators, emergency planning, radiation dose
National Category
Earth and Related Environmental Sciences Mechanical Engineering Radiology, Nuclear Medicine and Medical Imaging Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:su:diva-160573DOI: 10.1097/HP.0000000000000158ISI: 000344736600018PubMedID: 25353241OAI: oai:DiVA.org:su-160573DiVA, id: diva2:1255429
Available from: 2018-10-12 Created: 2018-10-12 Last updated: 2018-10-12Bibliographically approved

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Bajinskis, AinarsMarczyk, MichalPolanska, JoannaBenderitter, MarcHaghdoost, SiamakWojcik, Andrzej
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Department of Molecular Biosciences, The Wenner-Gren Institute
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Health Physics
Earth and Related Environmental SciencesMechanical EngineeringRadiology, Nuclear Medicine and Medical ImagingOccupational Health and Environmental Health

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