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Cryo-EM structure of the yeast respiratory supercomplex
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0001-9178-1006
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0001-6627-8134
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
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Number of Authors: 72019 (English)In: Nature Structural & Molecular Biology, ISSN 1545-9993, E-ISSN 1545-9985, Vol. 26, no 1, p. 50-57Article in journal (Refereed) Published
Abstract [en]

Respiratory chain complexes execute energy conversion by connecting electron transport with proton translocation over the inner mitochondrial membrane to fuel ATP synthesis. Notably, these complexes form multi-enzyme assemblies known as respiratory supercomplexes. Here we used single-particle cryo-EM to determine the structures of the yeast mitochondria! respiratory supercomplexes III2IV and III2IV2, at 3.2-angstrom and 3.5-angstrom resolutions, respectively. We revealed the overall architecture of the supercomplex, which deviates from the previously determined assemblies in mammals; obtained a near-atomic structure of the yeast complex IV; and identified the protein-protein and protein-lipid interactions implicated in supercomplex formation. Take together, our results demonstrate convergent evolution of supercomplexes in mitochondria that, while building similar assemblies, results in substantially different arrangements and structural solutions to support energy conversion.

Place, publisher, year, edition, pages
2019. Vol. 26, no 1, p. 50-57
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Biological Sciences
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URN: urn:nbn:se:su:diva-165785DOI: 10.1038/s41594-018-0169-7ISI: 000454902900007PubMedID: 30598556OAI: oai:DiVA.org:su-165785DiVA, id: diva2:1291803
Available from: 2019-02-26 Created: 2019-02-26 Last updated: 2019-02-26Bibliographically approved

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Rathore, SorbhiBerndtsson, JensConrad, JulianCarroni, MartaBrzezinski, PeterOtt, Martin
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