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The effect of a transient immune activation on subjective health perception in two placebo controlled randomised experiments
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Karolinska Institutet, Sweden.ORCID-id: 0000-0003-0203-7977
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Karolinska Institutet, Sweden.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Karolinska Institutet, Sweden.
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Rekke forfattare: 82019 (engelsk)Inngår i: PLOS ONE, E-ISSN 1932-6203, Vol. 14, nr 3, artikkel-id e0212313Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Patient-reported outcomes predict mortality and play increasingly important roles in care, but factors that modify central measures such as health ratings have been little investigated. Building on designated immune-to-brain pathways, we aimed to determine how a short-term induced inflammation response impacts self-reported health status. Methods Lipopolysaccharide injections were used to provoke acute systemic inflammatory responses in healthy men and women and were compared to placebo in two double-blind randomized experiments. In Experiment 1, 8 individuals (mean 24 years; SD = 3.7) received lipopolysaccharide 0.8 ng/kg once and placebo once in a cross-over design, and in Experiment 2, 52 individuals received either lipopolysaccharide 0.6 ng/kg or placebo once (28.6 years; SD = 7.1). Main outcomes were perceived health (general and current), sickness behaviour (like fatigue, pain and negative affect), and plasma interleukin-6, interleukin-8 and tumour necrosis factor-alpha, before and after injection. Results Compared to placebo, lipopolysaccharide lead to a deterioration in both self-rated general (Experiment 1, b = 1.88 for 0.8 ng/kg) and current health (Experiment 1 b = -3.00; and Experiment 2 b = -1.79) 1.5h after injection (p's<0.01), effects that remained after 4.5 to 5 hours (p's<0.05). The effect on current health in Experiment 2 was mediated by increased inflammation and sickness behaviour in response to lipopolysaccharide injection (beta = -0.28, p = 0.01). Conclusion Health is drastically re-evaluated during inflammatory activation. The findings are consistent with notions that inflammation forms part of health-relevant interoceptive computations of bodily state, and hint at one mechanism as to why subjective health predicts longevity.

sted, utgiver, år, opplag, sider
2019. Vol. 14, nr 3, artikkel-id e0212313
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URN: urn:nbn:se:su:diva-167495DOI: 10.1371/journal.pone.0212313ISI: 000460372100026PubMedID: 30840633OAI: oai:DiVA.org:su-167495DiVA, id: diva2:1301199
Tilgjengelig fra: 2019-04-01 Laget: 2019-04-01 Sist oppdatert: 2022-03-23bibliografisk kontrollert

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