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The vacuolar shapes of ageing: From function to morphology
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. University of Graz, Austria.
Number of Authors: 22019 (English)In: Biochimica et Biophysica Acta. Molecular Cell Research, ISSN 0167-4889, E-ISSN 1879-2596, Vol. 1866, no 5, p. 957-970Article, review/survey (Refereed) Published
Abstract [en]

Cellular ageing results in accumulating damage to various macromolecules and the progressive decline of organelle function. Yeast vacuoles as well as their counterpart in higher eukaryotes, the lysosomes, emerge as central organelles in lifespan determination. These acidic organelles integrate enzymatic breakdown and recycling of cellular waste with nutrient sensing, storage, signalling and mobilization. Establishing physical contact with virtually all other organelles, vacuoles serve as hubs of cellular homeostasis. Studies in Saccharomyces cerevisiae contributed substantially to our understanding of the ageing process per se and the multifaceted roles of vacuoles/lysosomes in the maintenance of cellular fitness with progressing age. Here, we discuss the multiple roles of the vacuole during ageing, ranging from vacuolar dynamics and acidification as determinants of lifespan to the function of this organelle as waste bin, recycling facility, nutrient reservoir and integrator of nutrient signalling.

Place, publisher, year, edition, pages
2019. Vol. 1866, no 5, p. 957-970
Keywords [en]
Vacuole, Ageing, Autophagy, Acidification, V-ATPase, Vacuolar fission and fusion
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-168319DOI: 10.1016/j.bbamcr.2019.02.011ISI: 000463275300017PubMedID: 30796938OAI: oai:DiVA.org:su-168319DiVA, id: diva2:1313475
Available from: 2019-05-03 Created: 2019-05-03 Last updated: 2019-05-03Bibliographically approved

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Aufschnaiter, AndreasBüttner, Sabrina
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