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Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2-/- Mice
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. University Medical Center Hamburg-Eppendorf, Germany.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 62019 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, no 4, article id 852Article in journal (Refereed) Published
Abstract [en]

The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in the regulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHA and low or high content of sucrose impact on metabolism in mice deficient for elongation of very long-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. We found that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, high fat challenge significantly increased body weight. This diet affected the triglyceride rich lipoprotein fraction of plasma lipoproteins and changed the expression of several genes involved in lipid metabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals is synergistically influenced by DHA dietary and sucrose content.

Place, publisher, year, edition, pages
2019. Vol. 11, no 4, article id 852
Keywords [en]
DHA deficiency, ELOVL2, DHA supplementation, high sucrose diet
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:su:diva-170175DOI: 10.3390/nu11040852ISI: 000467749800145PubMedID: 30991731OAI: oai:DiVA.org:su-170175DiVA, id: diva2:1329259
Available from: 2019-06-24 Created: 2019-06-24 Last updated: 2019-06-24Bibliographically approved

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Pauter, Anna M.Fischer, Alexander W.Bengtsson, ToreAsadi, AbolfazlTalamonti, EmanuelaJacobsson, Anders
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