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Biological effects of mixed-ion beams. Part 2: The relative biological effectiveness of CHO-K1 cells irradiated by mixed- and single-ion beams
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Number of Authors: 122019 (English)In: Applied Radiation and Isotopes, ISSN 0969-8043, E-ISSN 1872-9800, Vol. 150, p. 192-198Article in journal (Refereed) Published
Abstract [en]

The relative biological effectiveness (RBE) values were determined for single- and mixed-ion beams containing carbon and oxygen ions. The CHO-K1 cells were irradiated with beams with the linear energy transfer (LET) values of 236-300 and 461-470 keV/mu m for C-12 and O-16 ions, respectively. The RBE was estimated as a function of dose, survival fraction (SF) and LET. The SF was not affected by varying contributions of the constituent ions to the total mixed dose. The RBE has the same value for single-ion exposures with ions with LET 300 (C-12) and 470 keV/mu m (O-16).

Place, publisher, year, edition, pages
2019. Vol. 150, p. 192-198
Keywords [en]
Relative biological effectiveness, Ions beams, CHO-K1 cells
National Category
Radiology, Nuclear Medicine and Medical Imaging Other Medical Biotechnology
Identifiers
URN: urn:nbn:se:su:diva-170801DOI: 10.1016/j.apradiso.2018.12.001ISI: 000472704100028PubMedID: 30553541OAI: oai:DiVA.org:su-170801DiVA, id: diva2:1338365
Available from: 2019-07-22 Created: 2019-07-22 Last updated: 2019-07-22Bibliographically approved

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Czub, JoannaBanaś, DariuszWójcik, Andrzej
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Department of Molecular Biosciences, The Wenner-Gren Institute
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Radiology, Nuclear Medicine and Medical ImagingOther Medical Biotechnology

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