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Effect of work schedule on prospective antidepressant prescriptions in Sweden: a 2-year sex-stratified analysis using national drug registry data
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. International Agency for Research on Cancer, France.ORCID-id: 0000-0003-1502-2694
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet.
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet.ORCID-id: 0000-0001-8433-2405
Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Swansea University, UK.ORCID-id: 0000-0002-8105-0901
Antal upphovsmän: 42019 (Engelska)Ingår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 9, nr 1, artikel-id e023247Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction Depression-related mood disorders affect millions of people worldwide and contribute to substantial morbidity and disability, yet little is known about the effects of work scheduling on depression. This study used a large Swedish survey to prospectively examine the effects of work schedule on registry-based antidepressant prescriptions in females and males over a 2-year period. Methods The study was based on an approximately representative sample (n= 3980 males, 4663 females) of gainfully employed participants in the Swedish Longitudinal Occupational Survey of Health. Sex-stratified analyses were conducted using logistic regression. For exposure, eight categories described work schedule in 2008: ` regular days' (three categories of night work history: none, <= 3 years, 4+ years), 'night shift work', 'regular shift work (no nights)', 'rostered work (no nights)', 'flexible/non-regulated hours' and 'other'. For the primary outcome measure, all prescriptions coded N06A according to the Anatomical Therapeutic Chemical System were obtained from the Swedish National Prescribed Drug Register and dichotomised into 'any' or 'no' prescriptions between 2008 and 2010. Estimates were adjusted for potential sociodemographic, health and work confounders, and for prior depressive symptoms. Results In 2008, 22% of females versus 19% of males worked outside of regular daytime schedule. Registered antidepressant prescription rates in the postsurvey period were 11.4% for females versus 5.8% for males. In fully adjusted models, females in 'flexible/non-regulated' schedules showed an increased OR for prospective antidepressant prescriptions (OR= 2.01, 95% CI= 1.08 to 3.76). In males, odds ratios were most increased in those working 'other' schedules (OR= 1.72, 95% CI= 0.75 to 3.94) and 'Regular days with four or more years' history of night work' (OR= 1.54, 95% CI= 0.93 to 2.56). Conclusions This study's findings support a relationship between work schedule and prospective antidepressant prescriptions in the Swedish workforce. Future research should continue to assess sex-stratified relationships, using detailed shift work exposure categories and objective registry data where possible.

Ort, förlag, år, upplaga, sidor
2019. Vol. 9, nr 1, artikel-id e023247
Nationell ämneskategori
Arbetsmedicin och miljömedicin
Identifikatorer
URN: urn:nbn:se:su:diva-170877DOI: 10.1136/bmjopen-2018-023247ISI: 000471116800089PubMedID: 30782699OAI: oai:DiVA.org:su-170877DiVA, id: diva2:1338533
Tillgänglig från: 2019-07-23 Skapad: 2019-07-23 Senast uppdaterad: 2020-03-04Bibliografiskt granskad

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Hall, Amy L.Kecklund, GöranLeineweber, ConstanzeTucker, Philip
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