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Adrenoceptors in white, brown, and brite adipocytes
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 42019 (English)In: British Journal of Pharmacology, ISSN 0007-1188, E-ISSN 1476-5381, Vol. 176, no 14, p. 2416-2432Article, review/survey (Refereed) Published
Abstract [en]

Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides (lipogenesis), the breakdown of stored triglycerides (lipolysis), thermogenesis (heat production), glucose metabolism, and the secretion of adipocyte-derived hormones that can control whole-body energy homeostasis. These processes are regulated by the sympathetic nervous system through actions at different adrenoceptor subtypes expressed in adipose tissue depots. In this review, we have highlighted the role of adrenoceptor subtypes in white, brown, and brite adipocytes in both rodents and humans and have included detailed analysis of adrenoceptor expression in human adipose tissue and clonally derived adipocytes. We discuss important considerations when investigating adrenoceptor function in adipose tissue or adipocytes.

Place, publisher, year, edition, pages
2019. Vol. 176, no 14, p. 2416-2432
National Category
Biological Sciences Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:su:diva-170820DOI: 10.1111/bph.14631ISI: 000472784200007PubMedID: 30801689OAI: oai:DiVA.org:su-170820DiVA, id: diva2:1339522
Available from: 2019-07-30 Created: 2019-07-30 Last updated: 2019-07-30Bibliographically approved

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Bengtsson, ToreHutchinson, Dana S.
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