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Perfluoroalkyl Acids (PFAAs) in Children's Serum and Contribution from PFAA-Contaminated Drinking Water
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
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Antal upphovsmän: 82019 (Engelska)Ingår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 53, nr 19, s. 11447-11457Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We investigated associations between serum perfluoroalkyl acid (PFAA) concentrations in children aged 4, 8, and 12 years (sampled in 2008-2015; n = 57, 55, and 119, respectively) and exposure via placental transfer, breastfeeding, and ingestion of PFAA-contaminated drinking water. Sampling took place in Uppsala County, Sweden, where the drinking water has been historically contaminated with perfluorobutanesulfonate (PFBS), perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluoroheptanoate (PFHpA), and perfluorooctanoate (PFOA). PFOS showed the highest median concentrations in serum (3.8-5.3 ng g(-1) serum), followed by PFHxS (1.6-5.0 ng g(-1) serum), PFOA (2.0-2.5 ng g(-1) serum), and perfluorononanoate (PFNA) (0.59-0.69 ng g(-1) serum) in children. Including all children, serum PFOA, PFHxS, and PFOS concentrations (adjusted mean), respectively, per unit (ng g(-1) serum) of increase in the maternal serum level (at delivery), the associations being strongest for 4 year-old children. PFHxS and PFOS significantly increased 3.9 and 3.8%, respectively, per month of nursing, with the highest increase for 4 year-olds. PFOA, PFBS, PFHxS, and PFOS increased 1.2, 207, 7.4, and 0.93%, respectively, per month of cumulative drinking water exposure. Early life exposure to PFOA, PFHxS, and PFOS is an important determinant of serum concentrations in children, with the strongest influence on younger ages. Drinking water with low to moderate PFBS, PFHxS, PFOS, and PFOA contamination is an important source of exposure for children with background exposure from other sources.

Ort, förlag, år, upplaga, sidor
2019. Vol. 53, nr 19, s. 11447-11457
Nationell ämneskategori
Geovetenskap och miljövetenskap Naturresursteknik
Identifikatorer
URN: urn:nbn:se:su:diva-175737DOI: 10.1021/acs.est.9b01746ISI: 000488993500043PubMedID: 31476116OAI: oai:DiVA.org:su-175737DiVA, id: diva2:1369234
Tillgänglig från: 2019-11-11 Skapad: 2019-11-11 Senast uppdaterad: 2019-11-11Bibliografiskt granskad

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Benskin, Jonathan P.Sandblom, OskarAhrens, LutzWiberg, Karin
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Institutionen för miljövetenskap och analytisk kemi
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Environmental Science and Technology
Geovetenskap och miljövetenskapNaturresursteknik

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