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Divisive structures: Two billions years of biofilament evolution
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0003-2461-0877
2020 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Our understanding of the functional and regulatory complexity that existed in the eukaryotic progenitor is poor, and investigations have been hindered by our nebulous understanding of where eukaryotes stem from. Recently discovered archaeal lineages with hitherto unseen homology to eukaryotic systems suggest archaea can further our understanding of the eukaryotic cell’s ancestry. However, much of archaeal biology remains largely unexplored. Two eukaryotic systems with archaeal homologues, namely the actin and ESCRT-III protein filament systems, are essential for diverse processes in eukaryotic biology. In this thesis, we show that an archaeal homologue of ESCRT-III divides the cell under proteasomal regulation, a regulatory mechanism central to eukaryotic cell cycle regulation. Additionally, we show how predicted putative profilin and gelsolin homologues regulate the postulated proto-cytoskeleton of Asgard archaea. In investigating the function and regulation of these archaeal systems we demonstrate compelling parallels between archaeal and eukaryotic regulatory strategies which stresses the close evolutionary relationship that exists between these two domains.

Place, publisher, year, edition, pages
Stockholm: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University , 2020. , p. 43
Keywords [en]
Evolution, Archaea, Eukaryogenesis, ESCRT-III, Actin, Profilin, Gelsolin, Asgard, TACK, Sulfolobus, Cell division, Cytokinesis, Cytoskeleton, Heimdallarchaeota, Actin-binding protein
National Category
Biochemistry and Molecular Biology
Research subject
Molecular Bioscience
Identifiers
URN: urn:nbn:se:su:diva-180989ISBN: 978-91-7911-058-1 (print)ISBN: 978-91-7911-059-8 (electronic)OAI: oai:DiVA.org:su-180989DiVA, id: diva2:1426171
Public defence
2020-06-12, Sal P216, NPQ-huset, Svante Arrhenius väg 20 A, digitally via Zoom: Zoom Meeting ID: 638-3943-9290, https://stockholmuniversity.zoom.us/j/63839439290, Stockholm, 10:00 (English)
Opponent
Supervisors
Funder
Swedish Research Council, 621 2013 4685Wellcome trust, 203276/F/16/Z
Note

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 1: Manuscript. Paper 2: Manuscript. Paper 3: Manuscript.

Available from: 2020-05-18 Created: 2020-04-23 Last updated: 2020-05-26Bibliographically approved
List of papers
1. The proteasome controls ESCRT-III-mediated cell division in an archaeon
Open this publication in new window or tab >>The proteasome controls ESCRT-III-mediated cell division in an archaeon
(English)Manuscript (preprint) (Other academic)
Keywords
Archaea, ESCRT, Evolution, Eukaryogensis, Proteasome, Sulfolobus
National Category
Biochemistry and Molecular Biology
Research subject
Molecular Bioscience
Identifiers
urn:nbn:se:su:diva-180986 (URN)
Funder
Swedish Research Council, 621-2013-4685Wellcome trust, 203276/Z/16/Z
Available from: 2020-04-22 Created: 2020-04-22 Last updated: 2020-04-27Bibliographically approved
2. Heimdallarchaea encodes profilin with eukaryotic like actin regulation and polyproline binding
Open this publication in new window or tab >>Heimdallarchaea encodes profilin with eukaryotic like actin regulation and polyproline binding
(English)Manuscript (preprint) (Other academic)
Keywords
Actin, Profilin, Asgard, Archaea, Heimdallarchaeota, Eukaryogenesis
National Category
Biochemistry and Molecular Biology
Research subject
Molecular Bioscience
Identifiers
urn:nbn:se:su:diva-180987 (URN)
Funder
Swedish Research Council, 621-2013-4685Wellcome trust, 203276/F/16/Z
Available from: 2020-04-22 Created: 2020-04-22 Last updated: 2020-04-27Bibliographically approved
3. A putative gelsolin from Heimdallarchaeota possesses eukaryotic-like regulation of actin
Open this publication in new window or tab >>A putative gelsolin from Heimdallarchaeota possesses eukaryotic-like regulation of actin
(English)Manuscript (preprint) (Other academic)
Keywords
Archaea, Evolution, Eukaryogenesis, Gelsolin, Actin
National Category
Biochemistry and Molecular Biology
Research subject
Molecular Bioscience
Identifiers
urn:nbn:se:su:diva-180988 (URN)
Funder
Wellcome trust, 203276/Z/16/ZSwedish Research Council, 621-2013-4685
Available from: 2020-04-22 Created: 2020-04-22 Last updated: 2020-04-27Bibliographically approved

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4344454647484946 of 88
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